TY - JOUR
T1 - An APRIL to remember
T2 - Novel TNF ligands as therapeutic targets
AU - Dillon, Stacey R.
AU - Gross, Jane A.
AU - Ansell, Stephen M.
AU - Novak, Anne J.
PY - 2006/3
Y1 - 2006/3
N2 - Since their discovery in 1998, the two TNF family members APRIL and BLyS/ BAFF have received increasing attention. In addition to regulating normal B-cell development and immune responses, these molecules might be crucial in a diverse set of diseases, including autoimmunity and cancer. Although more has been published about the general biology of BLyS/BAFF than that of APRIL, many recent articles have described novel APRIL biology. Here we focus on APRIL, exploring its normal and pathological functions, and comparing the therapeutic molecules currently under development that target BLyS/BAFF alone, or APRIL and BLyS/BAFF together.
AB - Since their discovery in 1998, the two TNF family members APRIL and BLyS/ BAFF have received increasing attention. In addition to regulating normal B-cell development and immune responses, these molecules might be crucial in a diverse set of diseases, including autoimmunity and cancer. Although more has been published about the general biology of BLyS/BAFF than that of APRIL, many recent articles have described novel APRIL biology. Here we focus on APRIL, exploring its normal and pathological functions, and comparing the therapeutic molecules currently under development that target BLyS/BAFF alone, or APRIL and BLyS/BAFF together.
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U2 - 10.1038/nrd1982
DO - 10.1038/nrd1982
M3 - Review article
C2 - 16474316
AN - SCOPUS:33644755600
SN - 1474-1776
VL - 5
SP - 235
EP - 246
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 3
ER -