An analysis of the role of calcium in facilitation at the frog neuromuscular junction

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Abstract

Under appropriate conditions stimulation of the neuromuscular junction by a single impulse or a brief train causes subsequent impulses to release increased amounts of transmitter. It has been proposed that this facilitation of transmitter release is due to calcium which remains on release sites following the conditioning stimuli. This residual calcium hypothesis is examined in frog cutaneous pectoris muscle in the present study. The second component of facilitation is shown to depend on the amount of calcium present during tetanization as required by the residual calcium hypothesis. The quantitative behavior of the facilitation accompanying tetani of a number of frequencies and durations is found to be consistent with the residual calcium hypothesis. Quantitative analysis of facilitation leads to a description of the time course of removal of calcium from release sites which is discussed.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of Physiology
Volume237
Issue number1
StatePublished - 1974
Externally publishedYes

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Neuromuscular Junction
Anura
Calcium
Tetanus
Muscles
Skin

ASJC Scopus subject areas

  • Physiology

Cite this

An analysis of the role of calcium in facilitation at the frog neuromuscular junction. / Younkin, Steven G.

In: Journal of Physiology, Vol. 237, No. 1, 1974, p. 1-14.

Research output: Contribution to journalArticle

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