An algorithm for genetic testing of frontotemporal lobar degeneration

J. S. Goldman, Rosa V Rademakers, E. D. Huey, A. L. Boxer, R. Mayeux, B. L. Miller, Bradley F Boeve

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: To derive an algorithm for genetic testing of patients with frontotemporal lobar degeneration (FTLD). Methods: A literature search was performed to review the clinical and pathologic phenotypes and family history associated with each FTLD gene. Results: Based on the literature review, an algorithm was developed to allow clinicians to use the clinical and neuroimaging phenotypes of the patient and the family history and autopsy information to decide whether or not genetic testing is warranted, and if so, the order for appropriate tests. Conclusions: Recent findings in genetics, pathology, and imaging allow clinicians to use the clinical presentation of the patient with FTLD to inform genetic testing decisions.

Original languageEnglish (US)
Pages (from-to)475-483
Number of pages9
JournalNeurology
Volume76
Issue number5
DOIs
StatePublished - Feb 1 2011

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Frontotemporal Lobar Degeneration
Genetic Testing
Phenotype
Neuroimaging
Autopsy
Pathology
Genes

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

An algorithm for genetic testing of frontotemporal lobar degeneration. / Goldman, J. S.; Rademakers, Rosa V; Huey, E. D.; Boxer, A. L.; Mayeux, R.; Miller, B. L.; Boeve, Bradley F.

In: Neurology, Vol. 76, No. 5, 01.02.2011, p. 475-483.

Research output: Contribution to journalArticle

Goldman, J. S. ; Rademakers, Rosa V ; Huey, E. D. ; Boxer, A. L. ; Mayeux, R. ; Miller, B. L. ; Boeve, Bradley F. / An algorithm for genetic testing of frontotemporal lobar degeneration. In: Neurology. 2011 ; Vol. 76, No. 5. pp. 475-483.
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