An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

Medicine & Life Sciences

• Proteostasis 100%
• Amyloid beta-Protein Precursor 88%
• Amyloid 72%
• Presenilins 66%
• Alzheimer Disease 59%
• Amyloid Precursor Protein Secretases 56%
• Homeostasis 22%
• Chronology 21%
• Peptide Fragments 20%
• Phylogeny 18%
• Cell Adhesion Molecules 16%
• Apolipoproteins E 16%
• Brain 15%
• Neuronal Plasticity 14%
• Immunotherapy 13%
• Dementia 12%
• Cognitive Dysfunction 12%
• Immune System 12%
• Cognition 12%
• Linear Models 11%
• History 11%
• Research Personnel 10%
• Biomarkers 9%
• Pathology 9%
• Mutation 8%
• Genes 6%
• Proteins 5%
• Therapeutics 2%

Social Sciences

• dementia 76%
• brain 25%
• loss of function 25%
• phylogeny 21%
• cognitive impairment 18%
• linear model 16%
• mismatch 15%
• pathology 14%
• cognition 12%
• event 8%
• history 8%