An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

Antonio M. Jimenez Jimenez; Marcos De Lima; Krishna V. Komanduri; Trent P. Wang; Mei Jie Zhang; Karen Chen; Hisham Abdel-Azim; Muhammad Bilal Abid; Mahmoud Aljurf; Hassan Alkhateeb; Amer Assal; Ulrike Bacher; Frédéric Baron; Minoo Battiwalla; Amer Beitinjaneh; Nelli Bejanyan; Vijaya Raj Bhatt; Michael Byrne; Jean Yves Cahn; Mitchell Cairo; Paul Castillo; Edward Copelan; Zachariah DeFilipp; Miguel Angel Diaz Perez; Mahmoud Elsawy; Robert Peter Gale; Biju George; Michael R. Grunwald; Gerhard C. Hildebrandt; William J. Hogan; Christopher G. Kanakry; Ankit Kansagra; Mohamed A. Kharfan-Dabaja; Nandita Khera; Maxwell M. Krem; Aleksandr Lazaryan; Joseph Maakaron; Rodrigo Martino; Joseph McGuirk; Fotios V. Michelis; Giuseppe Milone; Asmita Mishra; Hemant S. Murthy; Alberto Mussetti; Sunita Nathan; Taiga Nishihori; Richard F. Olsson; Neil Palmisiano; Sagar Patel; Ayman Saad; Sachiko Seo; Akshay Sharma; Melhem Solh; Leo F. Verdonck; Baldeep Wirk; Jean A. Yared; Mark Litzow; Partow Kebriaei; Christopher S. Hourigan; Wael Saber; Daniel Weisdorf

doi:10.1038/s41409-021-01450-3

An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

Antonio M. Jimenez Jimenez, Marcos De Lima, Krishna V. Komanduri, Trent P. Wang, Mei Jie Zhang, Karen Chen, Hisham Abdel-Azim, Muhammad Bilal Abid, Mahmoud Aljurf, Hassan Alkhateeb, Amer Assal, Ulrike Bacher, Frédéric Baron, Minoo Battiwalla, Amer Beitinjaneh, Nelli Bejanyan, Vijaya Raj Bhatt, Michael Byrne, Jean Yves Cahn, Mitchell CairoPaul Castillo, Edward Copelan, Zachariah DeFilipp, Miguel Angel Diaz Perez, Mahmoud Elsawy, Robert Peter Gale, Biju George, Michael R. Grunwald, Gerhard C. Hildebrandt, William J. Hogan, Christopher G. Kanakry, Ankit Kansagra, Mohamed A. Kharfan-Dabaja, Nandita Khera, Maxwell M. Krem, Aleksandr Lazaryan, Joseph Maakaron, Rodrigo Martino, Joseph McGuirk, Fotios V. Michelis, Giuseppe Milone, Asmita Mishra, Hemant S. Murthy, Alberto Mussetti, Sunita Nathan, Taiga Nishihori, Richard F. Olsson, Neil Palmisiano, Sagar Patel, Ayman Saad, Sachiko Seo, Akshay Sharma, Melhem Solh, Leo F. Verdonck, Baldeep Wirk, Jean A. Yared, Mark Litzow, Partow Kebriaei, Christopher S. Hourigan, Wael Saber, Daniel Weisdorf

Research output: Contribution to journal › Article › peer-review

Abstract

Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p ≤ 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.

Original language	English (US)
Pages (from-to)	3068-3077
Number of pages	10
Journal	Bone Marrow Transplantation
Volume	56
Issue number	12
DOIs	https://doi.org/10.1038/s41409-021-01450-3
State	Published - Dec 2021

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/s41409-021-01450-3

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Jimenez Jimenez, A. M., De Lima, M., Komanduri, K. V., Wang, T. P., Zhang, M. J., Chen, K., Abdel-Azim, H., Abid, M. B., Aljurf, M., Alkhateeb, H., Assal, A., Bacher, U., Baron, F., Battiwalla, M., Beitinjaneh, A., Bejanyan, N., Bhatt, V. R., Byrne, M., Cahn, J. Y., ... Weisdorf, D. (2021). An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis. Bone Marrow Transplantation, 56(12), 3068-3077. https://doi.org/10.1038/s41409-021-01450-3

An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis. / Jimenez Jimenez, Antonio M.; De Lima, Marcos; Komanduri, Krishna V. et al.
In: Bone Marrow Transplantation, Vol. 56, No. 12, 12.2021, p. 3068-3077.

Research output: Contribution to journal › Article › peer-review

Jimenez Jimenez, AM, De Lima, M, Komanduri, KV, Wang, TP, Zhang, MJ, Chen, K, Abdel-Azim, H, Abid, MB, Aljurf, M, Alkhateeb, H, Assal, A, Bacher, U, Baron, F, Battiwalla, M, Beitinjaneh, A, Bejanyan, N, Bhatt, VR, Byrne, M, Cahn, JY, Cairo, M, Castillo, P, Copelan, E, DeFilipp, Z, Perez, MAD, Elsawy, M, Gale, RP, George, B, Grunwald, MR, Hildebrandt, GC, Hogan, WJ, Kanakry, CG, Kansagra, A, Kharfan-Dabaja, MA, Khera, N, Krem, MM, Lazaryan, A, Maakaron, J, Martino, R, McGuirk, J, Michelis, FV, Milone, G, Mishra, A, Murthy, HS, Mussetti, A, Nathan, S, Nishihori, T, Olsson, RF, Palmisiano, N, Patel, S, Saad, A, Seo, S, Sharma, A, Solh, M, Verdonck, LF, Wirk, B, Yared, JA, Litzow, M, Kebriaei, P, Hourigan, CS, Saber, W & Weisdorf, D 2021, 'An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis', Bone Marrow Transplantation, vol. 56, no. 12, pp. 3068-3077. https://doi.org/10.1038/s41409-021-01450-3

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title = "An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis",

abstract = "Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p ≤ 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.",

author = "{Jimenez Jimenez}, {Antonio M.} and {De Lima}, Marcos and Komanduri, {Krishna V.} and Wang, {Trent P.} and Zhang, {Mei Jie} and Karen Chen and Hisham Abdel-Azim and Abid, {Muhammad Bilal} and Mahmoud Aljurf and Hassan Alkhateeb and Amer Assal and Ulrike Bacher and Fr{\'e}d{\'e}ric Baron and Minoo Battiwalla and Amer Beitinjaneh and Nelli Bejanyan and Bhatt, {Vijaya Raj} and Michael Byrne and Cahn, {Jean Yves} and Mitchell Cairo and Paul Castillo and Edward Copelan and Zachariah DeFilipp and Perez, {Miguel Angel Diaz} and Mahmoud Elsawy and Gale, {Robert Peter} and Biju George and Grunwald, {Michael R.} and Hildebrandt, {Gerhard C.} and Hogan, {William J.} and Kanakry, {Christopher G.} and Ankit Kansagra and Kharfan-Dabaja, {Mohamed A.} and Nandita Khera and Krem, {Maxwell M.} and Aleksandr Lazaryan and Joseph Maakaron and Rodrigo Martino and Joseph McGuirk and Michelis, {Fotios V.} and Giuseppe Milone and Asmita Mishra and Murthy, {Hemant S.} and Alberto Mussetti and Sunita Nathan and Taiga Nishihori and Olsson, {Richard F.} and Neil Palmisiano and Sagar Patel and Ayman Saad and Sachiko Seo and Akshay Sharma and Melhem Solh and Verdonck, {Leo F.} and Baldeep Wirk and Yared, {Jean A.} and Mark Litzow and Partow Kebriaei and Hourigan, {Christopher S.} and Wael Saber and Daniel Weisdorf",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2021",

month = dec,

doi = "10.1038/s41409-021-01450-3",

language = "English (US)",

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TY - JOUR

T1 - An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

AU - Jimenez Jimenez, Antonio M.

AU - De Lima, Marcos

AU - Komanduri, Krishna V.

AU - Wang, Trent P.

AU - Zhang, Mei Jie

AU - Chen, Karen

AU - Abdel-Azim, Hisham

AU - Abid, Muhammad Bilal

AU - Aljurf, Mahmoud

AU - Alkhateeb, Hassan

AU - Assal, Amer

AU - Bacher, Ulrike

AU - Baron, Frédéric

AU - Battiwalla, Minoo

AU - Beitinjaneh, Amer

AU - Bejanyan, Nelli

AU - Bhatt, Vijaya Raj

AU - Byrne, Michael

AU - Cahn, Jean Yves

AU - Cairo, Mitchell

AU - Castillo, Paul

AU - Copelan, Edward

AU - DeFilipp, Zachariah

AU - Perez, Miguel Angel Diaz

AU - Elsawy, Mahmoud

AU - Gale, Robert Peter

AU - George, Biju

AU - Grunwald, Michael R.

AU - Hildebrandt, Gerhard C.

AU - Hogan, William J.

AU - Kanakry, Christopher G.

AU - Kansagra, Ankit

AU - Kharfan-Dabaja, Mohamed A.

AU - Khera, Nandita

AU - Krem, Maxwell M.

AU - Lazaryan, Aleksandr

AU - Maakaron, Joseph

AU - Martino, Rodrigo

AU - McGuirk, Joseph

AU - Michelis, Fotios V.

AU - Milone, Giuseppe

AU - Mishra, Asmita

AU - Murthy, Hemant S.

AU - Mussetti, Alberto

AU - Nathan, Sunita

AU - Nishihori, Taiga

AU - Olsson, Richard F.

AU - Palmisiano, Neil

AU - Patel, Sagar

AU - Saad, Ayman

AU - Seo, Sachiko

AU - Sharma, Akshay

AU - Solh, Melhem

AU - Verdonck, Leo F.

AU - Wirk, Baldeep

AU - Yared, Jean A.

AU - Litzow, Mark

AU - Kebriaei, Partow

AU - Hourigan, Christopher S.

AU - Saber, Wael

AU - Weisdorf, Daniel

PY - 2021/12

Y1 - 2021/12

N2 - Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p ≤ 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.

AB - Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p ≤ 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.

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JO - Bone Marrow Transplantation

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ER -

An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

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