An 8-year-old boy with hypereosinophilic syndrome

Koa Hosoki, Mizuho Nagao, Kosei Iguchi, Toshiaki Ihara, Yoshiyuki Yamada, Masamune Higashigawa, Gail M. Kephart, Hirohito Kita, Takao Fujisawa

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Hypereosinophilic syndrome (HES) is a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia and tissue eosinophilia, resulting in a wide variety of clinical manifestations. We present the case of an 8-year-old boy with HES. He complained of recurrent abdominal pain, general fatigue, and diarrhea. Laboratory data showed marked eosinophilia, elevated total IgE with positive specific IgE antibodies to common inhalant and food allergens, and elevated serum CCL17/TARC. A chest CT scan revealed central bronchiectasis, bronchial wall thickening, a mosaic attenuation pattern, and multiple small nodules in lung parenchyma; abdominal CT showed a thickened bladder wall. Gastrointestinal endoscopy revealed scarring in the gastric mucosa and mucosal erosion in the duodenum. Immunohistochemical examination demonstrated numerous eosinophil infiltrations with extensive extracellular eosinophil major basic protein deposition in the gastric mucosa. Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect. HES is extraordinary rare in children and the long-term prognosis in pediatric HES is not well known. Comprehensive diagnostic procedures are vital for the early detection and management of complications in pediatric HES.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalInternational archives of allergy and immunology
Volume155
Issue numberSUPPL. 1
DOIs
StatePublished - Jun 2011

Keywords

  • Helicobacter pylori
  • Hypereosinophilic syndrome
  • Prednisolone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'An 8-year-old boy with hypereosinophilic syndrome'. Together they form a unique fingerprint.

  • Cite this

    Hosoki, K., Nagao, M., Iguchi, K., Ihara, T., Yamada, Y., Higashigawa, M., Kephart, G. M., Kita, H., & Fujisawa, T. (2011). An 8-year-old boy with hypereosinophilic syndrome. International archives of allergy and immunology, 155(SUPPL. 1), 117-122. https://doi.org/10.1159/000327495