Amyloidosis: Diagnosis and prognosis

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

All patients with amyloidosis must have Congo red-stained deposits demonstrating green birefringence under polarized light. Subcutaneous fat is the easiest source for such tissue. Amyloid deposits must be characterized to establish systemic or localized disease, and all forms of systemic amyloidosis must be classified using immunohistochemistry, immunofluorescence, genetic testing for mutations known to be associated with familial amyloidosis or mass spectroscopy techniques. Where available, serum amyloid P component imaging may be used to quantify the extent of amyloid deposition. Both echocardiography and magnetic resonance imaging are important tools for assessing the extent of cardiac amyloidosis and establishing the prognosis for patients with this disease.

Original languageEnglish (US)
Pages (from-to)369-380
Number of pages12
JournalFuture Rheumatology
Volume3
Issue number4
DOIs
StatePublished - Aug 1 2008

Keywords

  • Amyloidosis
  • Brain natriuretic peptide
  • Congo red
  • Immunoglobulin free light chain
  • Immunoglobulin light chain
  • Monoclonal protein

ASJC Scopus subject areas

  • Rheumatology

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