Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease

M. R. Palmert, T. E. Golde, M. L. Cohen, D. M. Kovacs, R. E. Tanzi, J. F. Gusella, M. F. Usiak, L. H. Younkin, Steven G Younkin

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.

Original languageEnglish (US)
Pages (from-to)1080-1084
Number of pages5
JournalScience
Volume241
Issue number4869
StatePublished - 1988
Externally publishedYes

Fingerprint

Amyloid beta-Protein Precursor
Alzheimer Disease
Neurons
Messenger RNA
Locus Coeruleus
Protease Inhibitors
Amyloid
In Situ Hybridization
Brain

ASJC Scopus subject areas

  • General

Cite this

Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., ... Younkin, S. G. (1988). Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease. Science, 241(4869), 1080-1084.

Amyloid protein precursor messenger RNAs : Differential expression in Alzheimer's disease. / Palmert, M. R.; Golde, T. E.; Cohen, M. L.; Kovacs, D. M.; Tanzi, R. E.; Gusella, J. F.; Usiak, M. F.; Younkin, L. H.; Younkin, Steven G.

In: Science, Vol. 241, No. 4869, 1988, p. 1080-1084.

Research output: Contribution to journalArticle

Palmert, MR, Golde, TE, Cohen, ML, Kovacs, DM, Tanzi, RE, Gusella, JF, Usiak, MF, Younkin, LH & Younkin, SG 1988, 'Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease', Science, vol. 241, no. 4869, pp. 1080-1084.
Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF et al. Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease. Science. 1988;241(4869):1080-1084.
Palmert, M. R. ; Golde, T. E. ; Cohen, M. L. ; Kovacs, D. M. ; Tanzi, R. E. ; Gusella, J. F. ; Usiak, M. F. ; Younkin, L. H. ; Younkin, Steven G. / Amyloid protein precursor messenger RNAs : Differential expression in Alzheimer's disease. In: Science. 1988 ; Vol. 241, No. 4869. pp. 1080-1084.
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