Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease

M. R. Palmert; T. E. Golde; M. L. Cohen; D. M. Kovacs; R. E. Tanzi; J. F. Gusella; M. F. Usiak; L. H. Younkin; S. G. Younkin

doi:10.1126/science.2457949

Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease

M. R. Palmert, T. E. Golde, M. L. Cohen, D. M. Kovacs, R. E. Tanzi, J. F. Gusella, M. F. Usiak, L. H. Younkin, S. G. Younkin

Neuroscience

Research output: Contribution to journal › Article › peer-review

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Abstract

In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.

Original language	English (US)
Pages (from-to)	1080-1084
Number of pages	5
Journal	Science
Volume	241
Issue number	4869
DOIs	https://doi.org/10.1126/science.2457949
State	Published - 1988

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title = "Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease",

abstract = "In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.",

author = "Palmert, {M. R.} and Golde, {T. E.} and Cohen, {M. L.} and Kovacs, {D. M.} and Tanzi, {R. E.} and Gusella, {J. F.} and Usiak, {M. F.} and Younkin, {L. H.} and Younkin, {S. G.}",

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language = "English (US)",

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T1 - Amyloid protein precursor messenger RNAs

T2 - Differential expression in Alzheimer's disease

AU - Palmert, M. R.

AU - Golde, T. E.

AU - Cohen, M. L.

AU - Kovacs, D. M.

AU - Tanzi, R. E.

AU - Gusella, J. F.

AU - Usiak, M. F.

AU - Younkin, L. H.

AU - Younkin, S. G.

PY - 1988

Y1 - 1988

N2 - In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.

AB - In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.

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Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer's disease

Abstract

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