Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain

Kendra L. Puig, Stephen A. Brose, Xudong Zhou, Mary A. Sens, Gerald F. Combs, Michael Dennis Jensen, Mikhail Y. Golovko, Colin K. Combs

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It is well known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal dominant forms of Alzheimer's disease. Proteolytic processing of the protein leads to a number of metabolites including the amyloid beta peptide. Although brain amyloid precursor protein expression and amyloid beta production are associated with the pathophysiology of Alzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell types and tissues. Here we demonstrate that amyloid precursor protein is involved in regulating the phenotype of both adipocytes and peripheral macrophages and is required for high fat diet-dependent weight gain in mice. These data suggest that functions of this protein include modulation of the peripheral immune system and lipid metabolism. This biology may have relevance not only to the pathophysiology of Alzheimer's disease but also diet-associated obesity.

Original languageEnglish (US)
Article number43725
JournalScientific Reports
Volume7
DOIs
StatePublished - Mar 6 2017

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Amyloid beta-Protein Precursor
Weight Gain
Macrophages
Diet
Phenotype
Alzheimer Disease
Amyloid beta-Peptides
High Fat Diet
Lipid Metabolism
Amyloid
Adipocytes
Immune System
Proteins
Obesity
Mutation
Brain
Genes

ASJC Scopus subject areas

  • General

Cite this

Puig, K. L., Brose, S. A., Zhou, X., Sens, M. A., Combs, G. F., Jensen, M. D., ... Combs, C. K. (2017). Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. Scientific Reports, 7, [43725]. https://doi.org/10.1038/srep43725

Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. / Puig, Kendra L.; Brose, Stephen A.; Zhou, Xudong; Sens, Mary A.; Combs, Gerald F.; Jensen, Michael Dennis; Golovko, Mikhail Y.; Combs, Colin K.

In: Scientific Reports, Vol. 7, 43725, 06.03.2017.

Research output: Contribution to journalArticle

Puig, KL, Brose, SA, Zhou, X, Sens, MA, Combs, GF, Jensen, MD, Golovko, MY & Combs, CK 2017, 'Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain', Scientific Reports, vol. 7, 43725. https://doi.org/10.1038/srep43725
Puig, Kendra L. ; Brose, Stephen A. ; Zhou, Xudong ; Sens, Mary A. ; Combs, Gerald F. ; Jensen, Michael Dennis ; Golovko, Mikhail Y. ; Combs, Colin K. / Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. In: Scientific Reports. 2017 ; Vol. 7.
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