Amyloid localized to tenosynovium at carpal tunnel release. Immunohistochemical identification of amyloid type

R. A. Kyle, Morie Gertz, R. P. Linke

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Thirty-five patients seen at the Mayo Clinic from 1968 to 1977 who had carpal tunnel syndrome and local deposition of amyloid without evidence of systemic amyloidosis were identified. The unlabeled immunoperoxidase method was used with antisera against purified amyloid proteins of the AA, Aκ, Aλ, AF/ASC1 (prealbumin) (transthyretin), and AB (β2-microglobulin) types. In 33 of the 35 patients, amyloid stained with antisera to transthyretin; in the remaining 2 patients, the amyloid did not stain with any antisera. Nine of the 35 patients had a monoclonal protein in the serum, and 2 had a monoclonal light chain in the urine. Systemic amyloidosis or multiple myeloma did not develop in any of these 11 patients. During follow-up, systemic amyloidosis developed in only 2 of the 35 patients: 1 had senile systemic amyloidosis and 1 had tissue that was inadequate for immunohistochemical staining. Amyloid localized to the tenosynovium consists of transthyretin, and systemic amyloidosis rarely develops.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number2
DOIs
StatePublished - Jan 1 1992

Fingerprint

Wrist
Amyloid
Amyloidosis
Prealbumin
Immune Sera
Serum Amyloid A Protein
Carpal Tunnel Syndrome
Multiple Myeloma
Blood Proteins
Coloring Agents
Urine
Staining and Labeling
Light

Keywords

  • Amyloid
  • Carpal tunnel
  • Immunohistochemical
  • Localized amyloid
  • Prealbumin
  • Transthyretin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Amyloid localized to tenosynovium at carpal tunnel release. Immunohistochemical identification of amyloid type. / Kyle, R. A.; Gertz, Morie; Linke, R. P.

In: American Journal of Clinical Pathology, Vol. 97, No. 2, 01.01.1992, p. 250-253.

Research output: Contribution to journalArticle

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