Amyloid-like Pulmonary Nodules, Including Localized Light-Chain Deposition: Clinicopathologic Analysis of Three Cases

Andras Khoor, Jeffrey L. Myers, Henry D. Tazelaar, Paul J. Kurtin

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance in other clinical contexts is unknown. We examined biopsy specimens of amyloid-like pulmonary nodules from 3 women without systemic light-chain deposition disease. Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of κ light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. Patients 2 (aged 65 years) and 3 (aged 69 years) had asymptomatic solitary pulmonary nodules. In all cases, electron microscopic examination showed dense granular extracellular deposits without the fibrillary characteristics of amyloid. Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalAmerican journal of clinical pathology
Volume121
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Amyloid-like
  • Immunohistochemical staining
  • Light-chain deposition disease
  • Pulmonary amyloidosis
  • Pulmonary nodules

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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