TY - JOUR
T1 - Amyloid-like Pulmonary Nodules, Including Localized Light-Chain Deposition
T2 - Clinicopathologic Analysis of Three Cases
AU - Khoor, Andras
AU - Myers, Jeffrey L.
AU - Tazelaar, Henry D.
AU - Kurtin, Paul J.
PY - 2004/2
Y1 - 2004/2
N2 - Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance in other clinical contexts is unknown. We examined biopsy specimens of amyloid-like pulmonary nodules from 3 women without systemic light-chain deposition disease. Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of κ light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. Patients 2 (aged 65 years) and 3 (aged 69 years) had asymptomatic solitary pulmonary nodules. In all cases, electron microscopic examination showed dense granular extracellular deposits without the fibrillary characteristics of amyloid. Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.
AB - Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance in other clinical contexts is unknown. We examined biopsy specimens of amyloid-like pulmonary nodules from 3 women without systemic light-chain deposition disease. Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of κ light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. Patients 2 (aged 65 years) and 3 (aged 69 years) had asymptomatic solitary pulmonary nodules. In all cases, electron microscopic examination showed dense granular extracellular deposits without the fibrillary characteristics of amyloid. Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.
KW - Amyloid-like
KW - Immunohistochemical staining
KW - Light-chain deposition disease
KW - Pulmonary amyloidosis
KW - Pulmonary nodules
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U2 - 10.1309/3GECPW2402F6V8EK
DO - 10.1309/3GECPW2402F6V8EK
M3 - Article
C2 - 14983932
AN - SCOPUS:0942287715
SN - 0002-9173
VL - 121
SP - 200
EP - 204
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 2
ER -