Amyloid arthropathy in smoldering myeloma: Do not take it lightly

Eli Muchtar, Rebecca L. King, Ellen D. McPhail, Matthew P. Thorpe, Wilson Gonsalves, Floranne Ernste, Martha Grogan, Angela Dispenzieri, Morie Gertz

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of smoldering multiple myeloma patient who developed signs and symptoms consistent with polyarthritis. A PET-CT demonstrated marked FDG activity in multiple joints, concerning for inflammatory arthritis. Arthrocentesis from the glenohumeral joint was consistent with inflammatory synovial fluid with no evidence for infection or crystals. Congo-red stain of the synovial fluid was positive, and mass-spectrometry based amyloid typing was consistent with wild-type transthyretin type. The patient responded instantly to glucocorticoids. This case reports highlights the feasibility of non-tissue diagnosis of amyloidosis using body fluids and underscores the importance of accurate typing to avoid erroneous treatment

Original languageEnglish (US)
Article number100242
JournalLeukemia Research Reports
Volume15
DOIs
StatePublished - Jan 2021

Keywords

  • Amyloidosis
  • Arthrocentesis
  • Arthropathic
  • Congo red

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Amyloid arthropathy in smoldering myeloma: Do not take it lightly'. Together they form a unique fingerprint.

Cite this