Amplified nocturnal Luteinizing Hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in Healthy aged men

Possible Leydig cell desensitization to endogenous LH signaling - A clinical research center study

Thomas Mulligan, Ali Iranmanesh, Sylvia Gheorghiu, Michael Godschalk, Johannes D Veldhuis

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The specific mechanisms underlying the relative hypogonadism of aging remain to be elucidated fully. We used frequent venous sampling (every 2.5 min), sensitive and specific LH and testosterone assays, and deconvolution analysis of the endocrine time series to delineate the differences between healthy young (n = 10, age 21-34 yr) and aged (n = 8, age 62-74 yr) men in the nocturnal secretion of LH and testosterone and their half-lives. We found that elderly men us. young men had more frequent bursts of LH secretion (1.4 vs. 0.9/h, P = 0.003), less testosterone secreted per testosterone secretory burst (9.2 vs. 17.0 nmol/L, P = 0.021), and less testosterone secreted per hour (10.7 vs. 25.0 nmol/L·h, P = 0.05). As the frequency of nocturnal LH secretory bursts increased, the frequency of testosterone bursts decreased (r = -0.746, P = 0.034). We conclude that healthy aging is associated with diminished nocturnal testosterone production attributable to 1) a decrement in the mass of testosterone released per burst and 2) an inadequate response by the pituitary gland to enhance testosterone production via an accelerated LH secretory pulse frequency. We speculate that this may reflect a partial desensitization of Leydig cells to LH.

Original languageEnglish (US)
Pages (from-to)3025-3031
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume80
Issue number10
StatePublished - Oct 1995
Externally publishedYes

Fingerprint

Leydig Cells
Luteinizing Hormone
Testosterone
Research
Aging of materials
Hypogonadism
Deconvolution
Pituitary Gland
Time series
Assays
Sampling

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Amplified nocturnal Luteinizing Hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in Healthy aged men: Possible Leydig cell desensitization to endogenous LH signaling - A clinical research center study",
abstract = "The specific mechanisms underlying the relative hypogonadism of aging remain to be elucidated fully. We used frequent venous sampling (every 2.5 min), sensitive and specific LH and testosterone assays, and deconvolution analysis of the endocrine time series to delineate the differences between healthy young (n = 10, age 21-34 yr) and aged (n = 8, age 62-74 yr) men in the nocturnal secretion of LH and testosterone and their half-lives. We found that elderly men us. young men had more frequent bursts of LH secretion (1.4 vs. 0.9/h, P = 0.003), less testosterone secreted per testosterone secretory burst (9.2 vs. 17.0 nmol/L, P = 0.021), and less testosterone secreted per hour (10.7 vs. 25.0 nmol/L·h, P = 0.05). As the frequency of nocturnal LH secretory bursts increased, the frequency of testosterone bursts decreased (r = -0.746, P = 0.034). We conclude that healthy aging is associated with diminished nocturnal testosterone production attributable to 1) a decrement in the mass of testosterone released per burst and 2) an inadequate response by the pituitary gland to enhance testosterone production via an accelerated LH secretory pulse frequency. We speculate that this may reflect a partial desensitization of Leydig cells to LH.",
author = "Thomas Mulligan and Ali Iranmanesh and Sylvia Gheorghiu and Michael Godschalk and Veldhuis, {Johannes D}",
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T1 - Amplified nocturnal Luteinizing Hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in Healthy aged men

T2 - Possible Leydig cell desensitization to endogenous LH signaling - A clinical research center study

AU - Mulligan, Thomas

AU - Iranmanesh, Ali

AU - Gheorghiu, Sylvia

AU - Godschalk, Michael

AU - Veldhuis, Johannes D

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N2 - The specific mechanisms underlying the relative hypogonadism of aging remain to be elucidated fully. We used frequent venous sampling (every 2.5 min), sensitive and specific LH and testosterone assays, and deconvolution analysis of the endocrine time series to delineate the differences between healthy young (n = 10, age 21-34 yr) and aged (n = 8, age 62-74 yr) men in the nocturnal secretion of LH and testosterone and their half-lives. We found that elderly men us. young men had more frequent bursts of LH secretion (1.4 vs. 0.9/h, P = 0.003), less testosterone secreted per testosterone secretory burst (9.2 vs. 17.0 nmol/L, P = 0.021), and less testosterone secreted per hour (10.7 vs. 25.0 nmol/L·h, P = 0.05). As the frequency of nocturnal LH secretory bursts increased, the frequency of testosterone bursts decreased (r = -0.746, P = 0.034). We conclude that healthy aging is associated with diminished nocturnal testosterone production attributable to 1) a decrement in the mass of testosterone released per burst and 2) an inadequate response by the pituitary gland to enhance testosterone production via an accelerated LH secretory pulse frequency. We speculate that this may reflect a partial desensitization of Leydig cells to LH.

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