Amplified centrosomes in breast cancer: A potential indicator of tumor aggressiveness

Antonino B. D'Assoro, Susan L. Barrett, Christopher Folk, Vivian C. Negron, Kelly Boeneman, Robert Busby, Clark Whitehead, Franca Stivala, Wilma L. Lingle, Jeffrey L. Salisbury

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Molecular mechanisms leading to genomic instability and phenotypic variation during tumor development and progression are poorly understood. Such instability represents a major problem in the management of breast cancer because of its contribution to more aggressive phenotypes as well as chemoresistance. In this study we analyzed breast carcinomas and tumor-derived cell lines to determine the relationship between centrosome amplification and established prognostic factors. Our results show that centrosome amplification can arise independent of ER or p53 status and is a common feature of aneuploid breast tumors. Centrosome amplification is associated with mitotic spindle abnormalities in breast carcinomas and thus may contribute to genomic instability and the development of more aggressive phenotypes during tumor progression.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalBreast Cancer Research and Treatment
Volume75
Issue number1
DOIs
StatePublished - Sep 1 2002

Keywords

  • Aneuploidy
  • Estrogen receptor
  • Microtubules
  • Mitotic spindle
  • p21
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    D'Assoro, A. B., Barrett, S. L., Folk, C., Negron, V. C., Boeneman, K., Busby, R., Whitehead, C., Stivala, F., Lingle, W. L., & Salisbury, J. L. (2002). Amplified centrosomes in breast cancer: A potential indicator of tumor aggressiveness. Breast Cancer Research and Treatment, 75(1), 25-34. https://doi.org/10.1023/A:1016550619925