TY - JOUR
T1 - Amniotic fluid glycine-valine ratio and neonatal morbidity in fetal growth restriction
AU - Bernstein, Ira M.
AU - Silver, Robert
AU - Nair, K. Sreekumaran
AU - Stirewalt, William S.
N1 - Funding Information:
Supported in part by National Institutes of Health grant R01 DK 41973 (SN).
PY - 1997/12
Y1 - 1997/12
N2 - Objective: To test the hypothesis that an elevated amniotic fluid glycine-valine ratio predicts neonatal morbidity in growth-restricted newborns. Methods: Amniotic fluid (AF) was collected from 122 third-trimester pregnancies (range 31-39 weeks), 49 of which were complicated by fetal growth restriction. Amino acid analysis was performed by high-pressure liquid chromatography. Glycine-valine ratios were compared between normal and growth-restricted fetuses. Neonatal morbidity within the group of growth- restricted fetuses was characterized by evaluation of neonatal hypoglycemia, arterial cord blood gas analysis, and birth weight percentile. We also examined the correlation of AF glycine-valine ratio to the umbilical artery resistance index. The median interval between AF sampling and delivery was 1 day (range 0-8 days). Analyses were performed by Student t test, χ2 with Yates correction, or simple correlation when appropriate. P < .03 was considered significant. Results: Growth-restricted fetuses have a significantly elevated AF glycine-valine ratio compared with control subjects (3.31 ± 1.06 versus 2.61 ± 0.77, respectively, P < .001). There was no association of the glycine-valine ratio with gestational age for either group. An elevated glycine-valine ratio was not associated with neonatal hypoglycemia within the growth-restricted group (hypoglycemia: [n = 16] 3.19 ± 1.07; no hypoglycemia: (n = 30) 3.44 ± 1.09). There were no significant correlations of glycine-valine ratio with arterial cord blood pH (r = - 0.10), oxygen pressure (r = 0.04), or base deficit (r = 0.12). There were no significant correlations of glycine-valine ratio and birth weight percentile (r = -.24) or umbilical artery resistance index (r = -.14). Conclusion: Amniotic fluid glycine-valine ratio is elevated in growth-restricted fetuses compared with control fetuses. However, the level of glycine-valine elevation is not associated with neonatal morbidity related to hypoglycemia, arterial cord blood gas abnormalities, or birth weight percentile.
AB - Objective: To test the hypothesis that an elevated amniotic fluid glycine-valine ratio predicts neonatal morbidity in growth-restricted newborns. Methods: Amniotic fluid (AF) was collected from 122 third-trimester pregnancies (range 31-39 weeks), 49 of which were complicated by fetal growth restriction. Amino acid analysis was performed by high-pressure liquid chromatography. Glycine-valine ratios were compared between normal and growth-restricted fetuses. Neonatal morbidity within the group of growth- restricted fetuses was characterized by evaluation of neonatal hypoglycemia, arterial cord blood gas analysis, and birth weight percentile. We also examined the correlation of AF glycine-valine ratio to the umbilical artery resistance index. The median interval between AF sampling and delivery was 1 day (range 0-8 days). Analyses were performed by Student t test, χ2 with Yates correction, or simple correlation when appropriate. P < .03 was considered significant. Results: Growth-restricted fetuses have a significantly elevated AF glycine-valine ratio compared with control subjects (3.31 ± 1.06 versus 2.61 ± 0.77, respectively, P < .001). There was no association of the glycine-valine ratio with gestational age for either group. An elevated glycine-valine ratio was not associated with neonatal hypoglycemia within the growth-restricted group (hypoglycemia: [n = 16] 3.19 ± 1.07; no hypoglycemia: (n = 30) 3.44 ± 1.09). There were no significant correlations of glycine-valine ratio with arterial cord blood pH (r = - 0.10), oxygen pressure (r = 0.04), or base deficit (r = 0.12). There were no significant correlations of glycine-valine ratio and birth weight percentile (r = -.24) or umbilical artery resistance index (r = -.14). Conclusion: Amniotic fluid glycine-valine ratio is elevated in growth-restricted fetuses compared with control fetuses. However, the level of glycine-valine elevation is not associated with neonatal morbidity related to hypoglycemia, arterial cord blood gas abnormalities, or birth weight percentile.
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U2 - 10.1016/S0029-7844(97)00533-4
DO - 10.1016/S0029-7844(97)00533-4
M3 - Article
C2 - 9397106
AN - SCOPUS:0030726372
SN - 0029-7844
VL - 90
SP - 933
EP - 937
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 6
ER -