Amnesia Following Basal Forebrain Lesions

Antonio R. Damasio, Neill R. Graff-Radford, Paul J. Eslinger, Hanna Damasio, Neal Kassell

Research output: Contribution to journalArticle

340 Scopus citations

Abstract

Of five patients with damage to the basal forebrain, four had lesions secondary to rupture of anterior cerebral or anterior communicating artery aneurysms, and one to the resection of an arteriovenous malformation. Computed tomographic scans and intraoperative reports confirmed damage to basal forebrain regions, which include septal nuclei, nucleus accumbens, substantia innominata, and related pathways. Behavioral disturbances featured a prominent amnesic syndrome and personality changes. The amnesia was distinguishable from that reported in patients HM and DRB and shared features with that seen in patients with Korsakoff's syndrome. We propose that the memory disorder can be explained by malfunctioning in the hippocampal system, secondary to damage in the basal forebrain structures with which it is strongly interconnected. The dysfunction might, in part, be caused by reduction of specific neurotransmitter innervation because the lesions are likely to damage cholinergic neurons and nearby catecholamine pathways within the basal forebrain.

Original languageEnglish (US)
Pages (from-to)263-271
Number of pages9
JournalArchives of neurology
Volume42
Issue number3
DOIs
StatePublished - Mar 1985

    Fingerprint

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this