Amino acid and poly(ethylene glycol) based self-organizing polymeric systems: Chemo-enzymatic synthesis and characterization

Rahul Tyagi, Rajesh Kumar, Mukesh K. Pandey, Jayant Kumar, Virinder S. Parmar, Arthur C. Watterson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) [PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a-c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a-c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications.

Original languageEnglish (US)
Pages (from-to)957-962
Number of pages6
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume45
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • Amphiphilic copolymer
  • Candida antarctica lipase
  • Chemo/regioselectivity
  • Micelle
  • Novozyme-435

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

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