Amino acid and poly(ethylene glycol) based self-organizing polymeric systems: Chemo-enzymatic synthesis and characterization

Rahul Tyagi; Rajesh Kumar; Mukesh K. Pandey; Jayant Kumar; Virinder S. Parmar; Arthur C. Watterson

doi:10.1080/10601320802380257

Amino acid and poly(ethylene glycol) based self-organizing polymeric systems: Chemo-enzymatic synthesis and characterization

Rahul Tyagi, Rajesh Kumar, Mukesh K. Pandey, Jayant Kumar, Virinder S. Parmar, Arthur C. Watterson

Radiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) [PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a-c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a-c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications.

Original language	English (US)
Pages (from-to)	957-962
Number of pages	6
Journal	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume	45
Issue number	11
DOIs	https://doi.org/10.1080/10601320802380257
State	Published - Nov 2008

Keywords

Amphiphilic copolymer
Candida antarctica lipase
Chemo/regioselectivity
Micelle
Novozyme-435

ASJC Scopus subject areas

Ceramics and Composites
Chemistry(all)
Polymers and Plastics
Materials Chemistry

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10.1080/10601320802380257

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title = "Amino acid and poly(ethylene glycol) based self-organizing polymeric systems: Chemo-enzymatic synthesis and characterization",

abstract = "A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) [PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a-c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a-c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications.",

keywords = "Amphiphilic copolymer, Candida antarctica lipase, Chemo/regioselectivity, Micelle, Novozyme-435",

author = "Rahul Tyagi and Rajesh Kumar and Pandey, {Mukesh K.} and Jayant Kumar and Parmar, {Virinder S.} and Watterson, {Arthur C.}",

note = "Funding Information: The authors are thankful to the University of Massachusetts Lowell for financial support.",

year = "2008",

month = nov,

doi = "10.1080/10601320802380257",

language = "English (US)",

volume = "45",

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T1 - Amino acid and poly(ethylene glycol) based self-organizing polymeric systems

T2 - Chemo-enzymatic synthesis and characterization

AU - Tyagi, Rahul

AU - Kumar, Rajesh

AU - Pandey, Mukesh K.

AU - Kumar, Jayant

AU - Parmar, Virinder S.

AU - Watterson, Arthur C.

N1 - Funding Information: The authors are thankful to the University of Massachusetts Lowell for financial support.

PY - 2008/11

Y1 - 2008/11

N2 - A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) [PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a-c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a-c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications.

AB - A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) [PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a-c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a-c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications.

KW - Amphiphilic copolymer

KW - Candida antarctica lipase

KW - Chemo/regioselectivity

KW - Micelle

KW - Novozyme-435

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VL - 45

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JO - Journal of Macromolecular Science - Pure and Applied Chemistry

JF - Journal of Macromolecular Science - Pure and Applied Chemistry

IS - 11

ER -

Amino acid and poly(ethylene glycol) based self-organizing polymeric systems: Chemo-enzymatic synthesis and characterization

Abstract

Keywords

ASJC Scopus subject areas

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