American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

William D. Travis, Talmadge E. King, Eric D. Bateman, David A. Lynch, Frédrique Capron, David Center, Thomas V. Colby, Jean François Cordier, Roland M. DuBois, Jeffrey Galvin, Philippe Grenier, David M. Hansell, Gary W. Hunninghake, Masanori Kitaichi, Nestor Luiz Müller, Jeffrey L. Myers, Sonoko Nagai, Andrew Nicholson, Ganesh Raghu, Benoit WallaertChristian G. Brambilla, Kevin K. Brown, Andrew L. Cherniaev, Ulrich Costabel, David B. Coultas, Gerald S. Davis, Maurits G. Demedts, William W. Douglas, J. Egan, Anders G. Eklund, Leonarda M. Fabbri, Craig A. Henke, Richard B. Hubbard, Y. Inoue, Takateru Izumi, H. M. Jansen, Ian Johnston, Dong Soon Kim, Nasreen Khalil, Fiona R. Lake, Giuseppe Lungarella, Joseph P. Lynch, Douglas W. Mapel, Fernando Martinez, Richard Matthay, Lee S. Newman, Paul W. Noble, Ken Ohta, Dario Olivieri, Luis A. Ortiz, Venerino Poletti, Robert Rodriguez-Roisin, William N. Rom, Jay Hoon Ryu, Paulo Saldiva, Raul H. Sansores, Marvin L. Schwarz, Moises Selman, Cecelia M. Smith, Zhaohui Tong, Zarir Udwadia, Dominique Valeyre, Athol Wells, Robert A. Wise, Antonio Xaubet, Emilio Alvarez Fernandez, E. Brambilla, Vera Capelozzi, Andrew Cherniaev, Peter Dalquen, Gerhard Dekan, P. S. Hasleton, James C. Hogg, N. A. Jambhekar, Anna Luise Katzenstein, Michael N. Koss, Osamu Matsubara, Klaus Michael Müller, F. B.J.M. Thunnissen, James A. Waldron, Wei Hua Li, Paul J. Friedman, Martin Remy-Jardin, Theresa C. McLoud

Research output: Contribution to journalArticle

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Abstract

Despite the considerable progress in the classification of the idiopathic interstitial pneumonias (IIPs), the lack of an international standard has resulted in variable and confusing diagnostic criteria and terminology. The advent of high-resolution computerized tomography, the narrowed pathologic definition of usual interstitial pneumonia (UIP) and recognition of the prognostic importance of separating UIP from other IIP patterns have profoundly changed the approach to the IIPs. This is an international Consensus Statement defining the clinical manifestations, pathology, and radiologic features of patients with IIP. The major objectives of this statement are to standardize the classification of the idiopathic interstitial pneumonias (IIPs) and to establish a uniform set of definitions and criteria for the diagnosis of IIPs. The targeted specialties are pulmonologists, radiologists, and pathologists. A multidisciplinary core panel was responsible for review of background articles and writing of the document. In addition, this group reviewed the clinical, radiologic, and pathologic aspects of a wide spectrum of cases of diffuse parenchymal interstitial lung diseases to establish a uniform and consistent approach to these diseases and to clarify the terminology, definitions, and descriptions used in routine clinical practice. The final statement was drafted after a series of meetings of the entire committee. The level of evidence for the recommendations made in this statement is largely that of expert opinion developed by consensus. This classification of IIPs includes seven clinico-radiologic-pathologic entities: idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia, cryptogenic organizing pneumonia, acute interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease, desquamative interstitial pneumonia, and lymphoid interstitial pneumonia. The need for dynamic interaction between pathologists, radiologists, and pulmonologists to accurately diagnose these disorders is emphasized. The level of evidence for the recommendations made in this Statement is largely that of expert opinion developed by consensus. This Statement is an integrated clinical, radiologic, and pathologic approach to the classification of the IIPs. Use of this international multidisciplinary classification will provide a standardized nomenclature and diagnostic criteria for IIP. This Statement provides a framework for the future study of these entities.

Original languageEnglish (US)
Pages (from-to)277-304
Number of pages28
JournalAmerican journal of respiratory and critical care medicine
Volume165
Issue number2
DOIs
StatePublished - Jan 15 2002

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Travis, W. D., King, T. E., Bateman, E. D., Lynch, D. A., Capron, F., Center, D., Colby, T. V., Cordier, J. F., DuBois, R. M., Galvin, J., Grenier, P., Hansell, D. M., Hunninghake, G. W., Kitaichi, M., Müller, N. L., Myers, J. L., Nagai, S., Nicholson, A., Raghu, G., ... McLoud, T. C. (2002). American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. American journal of respiratory and critical care medicine, 165(2), 277-304. https://doi.org/10.1164/ajrccm.165.2.ats01