TY - JOUR
T1 - American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in familial adenomatous polyposis syndromes
AU - Yang, Julie
AU - Gurudu, Suryakanth R.
AU - Koptiuch, Cathryn
AU - Agrawal, Deepak
AU - Buxbaum, James L.
AU - Abbas Fehmi, Syed M.
AU - Fishman, Douglas S.
AU - Khashab, Mouen A.
AU - Jamil, Laith H.
AU - Jue, Terry L.
AU - Law, Joanna K.
AU - Lee, Jeffrey K.
AU - Naveed, Mariam
AU - Qumseya, Bashar J.
AU - Sawhney, Mandeep S.
AU - Thosani, Nirav
AU - Wani, Sachin B.
AU - Samadder, N. Jewel
N1 - Publisher Copyright:
© 2020 American Society for Gastrointestinal Endoscopy
PY - 2020/5
Y1 - 2020/5
N2 - Familial adenomatous polyposis (FAP) syndrome is a complex entity, which includes FAP, attenuated FAP, and MUTYH-associated polyposis. These patients are at significant risk for colorectal cancer and carry additional risks for extracolonic malignancies. In this guideline, we reviewed the most recent literature to formulate recommendations on the role of endoscopy in this patient population. Relevant clinical questions were how to identify high-risk individuals warranting genetic testing, when to start screening examinations, what are appropriate surveillance intervals, how to identify endoscopically high-risk features, and what is the role of chemoprevention. A systematic literature search from 2005 to 2018 was performed, in addition to the inclusion of seminal historical studies. Most studies were from worldwide registries, which have compiled years of data regarding the natural history and cancer risks in this cohort. Given that most studies were retrospective, recommendations were based on epidemiologic data and expert opinion. Management of colorectal polyps in FAP has not changed much in recent years, as colectomy in FAP is the standard of care. What is new, however, is the developing body of literature on the role of endoscopy in managing upper GI and small-bowel polyposis, as patients are living longer and improved endoscopic technologies have emerged.
AB - Familial adenomatous polyposis (FAP) syndrome is a complex entity, which includes FAP, attenuated FAP, and MUTYH-associated polyposis. These patients are at significant risk for colorectal cancer and carry additional risks for extracolonic malignancies. In this guideline, we reviewed the most recent literature to formulate recommendations on the role of endoscopy in this patient population. Relevant clinical questions were how to identify high-risk individuals warranting genetic testing, when to start screening examinations, what are appropriate surveillance intervals, how to identify endoscopically high-risk features, and what is the role of chemoprevention. A systematic literature search from 2005 to 2018 was performed, in addition to the inclusion of seminal historical studies. Most studies were from worldwide registries, which have compiled years of data regarding the natural history and cancer risks in this cohort. Given that most studies were retrospective, recommendations were based on epidemiologic data and expert opinion. Management of colorectal polyps in FAP has not changed much in recent years, as colectomy in FAP is the standard of care. What is new, however, is the developing body of literature on the role of endoscopy in managing upper GI and small-bowel polyposis, as patients are living longer and improved endoscopic technologies have emerged.
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U2 - 10.1016/j.gie.2020.01.028
DO - 10.1016/j.gie.2020.01.028
M3 - Article
C2 - 32169282
AN - SCOPUS:85081240588
SN - 0016-5107
VL - 91
SP - 963-982.e2
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 5
ER -