American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems

Scott R. Hall; Gregory S. Neel; Brent A. Chang; Brittany E. Howard; Thomas H. Nagel; David G. Lott; Richard E. Hayden; Nan Zhang; Michael L. Hinni

doi:10.1002/hed.25749

American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems

Scott R. Hall, Gregory S. Neel, Brent A. Chang, Brittany E. Howard, Thomas H. Nagel, David G. Lott, Richard E. Hayden, Nan Zhang, Michael L. Hinni

Otolaryngology- Head & Neck Surgery/Audiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. Methods: In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p. Results: A total of 213 patients met inclusion criteria. Kappa statistics showed poor agreement (κ = 0.3275) between AJCC 8c and AJCC 8p. In total, 30.3% of patient's preoperative AJCC 8c stage changed based on the postoperative pathologic staging (AJCC 8p) with 73.4% of those being upstaged. Conclusion: These data suggest that disagreement exists between AJCC 8c and AJCC 8p, in part due to the separate clinical and pathological staging criteria. This discrepancy should be considered as the new system is implemented.

Original language	English (US)
Pages (from-to)	2716-2723
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	8
DOIs	https://doi.org/10.1002/hed.25749
State	Published - Aug 2019

Keywords

HPV positive oropharyngeal cancer
cancer staging

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25749

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Hall, S. R., Neel, G. S., Chang, B. A., Howard, B. E., Nagel, T. H., Lott, D. G., Hayden, R. E., Zhang, N., & Hinni, M. L. (2019). American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems. Head and Neck, 41(8), 2716-2723. https://doi.org/10.1002/hed.25749

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title = "American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems",

abstract = "Background: The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. Methods: In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p. Results: A total of 213 patients met inclusion criteria. Kappa statistics showed poor agreement (κ = 0.3275) between AJCC 8c and AJCC 8p. In total, 30.3% of patient's preoperative AJCC 8c stage changed based on the postoperative pathologic staging (AJCC 8p) with 73.4% of those being upstaged. Conclusion: These data suggest that disagreement exists between AJCC 8c and AJCC 8p, in part due to the separate clinical and pathological staging criteria. This discrepancy should be considered as the new system is implemented.",

keywords = "HPV positive oropharyngeal cancer, cancer staging",

author = "Hall, {Scott R.} and Neel, {Gregory S.} and Chang, {Brent A.} and Howard, {Brittany E.} and Nagel, {Thomas H.} and Lott, {David G.} and Hayden, {Richard E.} and Nan Zhang and Hinni, {Michael L.}",

year = "2019",

month = aug,

doi = "10.1002/hed.25749",

language = "English (US)",

volume = "41",

pages = "2716--2723",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

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T1 - American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system

T2 - Discordance between clinical and pathological staging systems

AU - Hall, Scott R.

AU - Neel, Gregory S.

AU - Chang, Brent A.

AU - Howard, Brittany E.

AU - Nagel, Thomas H.

AU - Lott, David G.

AU - Hayden, Richard E.

AU - Zhang, Nan

AU - Hinni, Michael L.

PY - 2019/8

Y1 - 2019/8

N2 - Background: The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. Methods: In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p. Results: A total of 213 patients met inclusion criteria. Kappa statistics showed poor agreement (κ = 0.3275) between AJCC 8c and AJCC 8p. In total, 30.3% of patient's preoperative AJCC 8c stage changed based on the postoperative pathologic staging (AJCC 8p) with 73.4% of those being upstaged. Conclusion: These data suggest that disagreement exists between AJCC 8c and AJCC 8p, in part due to the separate clinical and pathological staging criteria. This discrepancy should be considered as the new system is implemented.

AB - Background: The American Joint Committee on Cancer (AJCC) eighth edition introduces a staging system specific for human papilloma virus positive oropharyngeal cancer with separate clinical (AJCC 8c) and pathological (AJCC 8p) criteria. Methods: In this retrospective cohort study, preoperative imaging and pathology reports were used to stage patients based on the AJCC 8c and AJCC 8p criteria, respectively. The primary endpoint was agreement between AJCC 8c and AJCC 8p. Results: A total of 213 patients met inclusion criteria. Kappa statistics showed poor agreement (κ = 0.3275) between AJCC 8c and AJCC 8p. In total, 30.3% of patient's preoperative AJCC 8c stage changed based on the postoperative pathologic staging (AJCC 8p) with 73.4% of those being upstaged. Conclusion: These data suggest that disagreement exists between AJCC 8c and AJCC 8p, in part due to the separate clinical and pathological staging criteria. This discrepancy should be considered as the new system is implemented.

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KW - cancer staging

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American Joint Committee on Cancer eighth edition human papilloma virus positive oropharyngeal cancer staging system: Discordance between clinical and pathological staging systems

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