AME evidence series 001-the society for translational medicine: Clinical practice guidelines for diagnosis and early identification of sepsis in the hospital

Zhongheng Zhang, Nathan J. Smischney, Haibo Zhang, Sven Van Poucke, Panagiotis Tsirigotis, Jordi Rello, Patrick M. Honore, Win Sen Kuan, Juliet June Ray, Jiancang Zhou, You Shang, Yuetian Yu, Christian Jung, Chiara Robba, Fabio Silvio Taccone, Pietro Caironi, David Grimaldi, Stefan Hofer, George Dimopoulos, Marc LeoneSang Bum Hong, Mabrouk Bahloul, Laurent Argaud, Won Young Kim, Herbert D. Spapen, Jose Rodolfo Rocco

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Sepsis is a heterogeneous disease caused by an infection stimulus that triggers several complex local and systemic immuno-inflammatory reactions, which results in multiple organ dysfunction and significant morbidity and mortality. The diagnosis of sepsis is challenging because there is no gold standard for diagnosis. As a result, the clinical diagnosis of sepsis is ever changing to meet the clinical and research requirements. Moreover, although there are many novel biomarkers and screening tools for predicting the risk of sepsis, the diagnostic performance and effectiveness of these measures are less than satisfactory, and there is insufficient evidence to recommend clinical use of these new techniques. As a consequence, diagnostic criteria for sepsis need regular revision to cope with emerging evidence. This review aims to present the most updated information on diagnosis and early recognition of sepsis. Recommendations for clinical use of different diagnostic tools rely on the Grades of Recommendation Assessment, Development and Evaluation (GRADE) framework. Because most of the studies were observational and did not allow a reliable assessment of these tools, a two-step inference approach was employed. Future trials need to confirm or refute a particular index test and should directly explore relevant patient outcome parameters.

Original languageEnglish (US)
Pages (from-to)2654-2665
Number of pages12
JournalJournal of Thoracic Disease
Volume8
Issue number9
DOIs
StatePublished - 2016

Keywords

  • Diagnosis
  • Early identification
  • Sepsis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Zhang, Z., Smischney, N. J., Zhang, H., Van Poucke, S., Tsirigotis, P., Rello, J., Honore, P. M., Kuan, W. S., Ray, J. J., Zhou, J., Shang, Y., Yu, Y., Jung, C., Robba, C., Taccone, F. S., Caironi, P., Grimaldi, D., Hofer, S., Dimopoulos, G., ... Rocco, J. R. (2016). AME evidence series 001-the society for translational medicine: Clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. Journal of Thoracic Disease, 8(9), 2654-2665. https://doi.org/10.21037/jtd.2016.08.03