Alzheimer's disease disrupts rich club organization in brain connectivity networks

Madelaine Daianu, Emily L. Dennis, Neda Jahanshad, Talia M. Nir, Arthur W. Toga, Clifford R Jr. Jack, Michael W. Weiner, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Citations (Scopus)

Abstract

Diffusion imaging and brain connectivity analyses can monitor white matter deterioration, revealing how neural pathways break down in aging and Alzheimer's disease (AD). Here we tested how AD disrupts the 'rich club' effect - a network property found in the normal brain - where high-degree nodes in the connectivity network are more heavily interconnected with each other than expected by chance. We analyzed 3-Tesla whole-brain diffusion-weighted images (DWI) from 66 subjects (22 AD/44 normal elderly). We performed whole-brain tractography based on the orientation distribution functions. Connectivity matrices were compiled, representing the proportion of detected fibers interconnecting 68 cortical regions. As expected, AD patients had a lower nodal degree (average number of connections) in cortical regions implicated in the disease. Unexpectedly, the normalized rich club coefficient was higher in AD. AD disrupts cortical networks by removing connections; when these networks are thresholded, organizational properties are disrupted leading to additional new biomarkers of AD.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
Pages266-269
Number of pages4
DOIs
StatePublished - 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Fingerprint

Brain
Alzheimer Disease
Neural Pathways
Neuroimaging
Biomarkers
Distribution functions
Deterioration
Aging of materials
Imaging techniques
Fibers

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Daianu, M., Dennis, E. L., Jahanshad, N., Nir, T. M., Toga, A. W., Jack, C. R. J., ... Thompson, P. M. (2013). Alzheimer's disease disrupts rich club organization in brain connectivity networks. In Proceedings - International Symposium on Biomedical Imaging (pp. 266-269). [6556463] https://doi.org/10.1109/ISBI.2013.6556463

Alzheimer's disease disrupts rich club organization in brain connectivity networks. / Daianu, Madelaine; Dennis, Emily L.; Jahanshad, Neda; Nir, Talia M.; Toga, Arthur W.; Jack, Clifford R Jr.; Weiner, Michael W.; Thompson, Paul M.

Proceedings - International Symposium on Biomedical Imaging. 2013. p. 266-269 6556463.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Daianu, M, Dennis, EL, Jahanshad, N, Nir, TM, Toga, AW, Jack, CRJ, Weiner, MW & Thompson, PM 2013, Alzheimer's disease disrupts rich club organization in brain connectivity networks. in Proceedings - International Symposium on Biomedical Imaging., 6556463, pp. 266-269, 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013, San Francisco, CA, United States, 4/7/13. https://doi.org/10.1109/ISBI.2013.6556463
Daianu M, Dennis EL, Jahanshad N, Nir TM, Toga AW, Jack CRJ et al. Alzheimer's disease disrupts rich club organization in brain connectivity networks. In Proceedings - International Symposium on Biomedical Imaging. 2013. p. 266-269. 6556463 https://doi.org/10.1109/ISBI.2013.6556463
Daianu, Madelaine ; Dennis, Emily L. ; Jahanshad, Neda ; Nir, Talia M. ; Toga, Arthur W. ; Jack, Clifford R Jr. ; Weiner, Michael W. ; Thompson, Paul M. / Alzheimer's disease disrupts rich club organization in brain connectivity networks. Proceedings - International Symposium on Biomedical Imaging. 2013. pp. 266-269
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