Alzheimer's Disease and Other Dementias

Dominique Petit, Jacques Montplaisir, Bradley F Boeve

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Sleep anomalies are found in a variety of conditions causing dementia. Specific features of the sleep and electroencephalographic impairments vary in some respects, but a common pattern emerges. Sleep is usually more fragmented, both from more awakenings and from a longer duration of time awake; slow-wave sleep is decreased; spindles and K-complexes are less well formed or less numerous, so sleep stages are more difficult to distinguish; and rapid eye movement (REM) sleep may be reduced. Quantitative analyses show a slowing of the electroencephalogram (EEG) during wakefulness and, in Alzheimer's disease, during REM sleep. These impairments typically worsen with the progression of the disease. Demented patients are also more likely to present with periodic limb movements in sleep and respiratory disturbances. This chapter gives an overview of sleep disturbances, characteristics of sleep architecture and microstructure, and quantitative analyses of wakefulness and sleep EEG in a variety of conditions associated with dementia: Alzheimer's disease, progressive supranuclear palsy, Parkinson's disease, dementia with Lewy bodies, vascular dementia, Huntington's disease, Creutzfeldt-Jakob disease, and frontotemporal dementia.

Original languageEnglish (US)
Title of host publicationPrinciples and Practice of Sleep Medicine: Fifth Edition
PublisherElsevier Inc.
Pages1038-1047
Number of pages10
ISBN (Print)9781416066453
DOIs
StatePublished - Nov 2010

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Dementia
Alzheimer Disease
Sleep
Wakefulness
REM Sleep
Electroencephalography
Progressive Supranuclear Palsy
Lewy Body Disease
Frontotemporal Dementia
Creutzfeldt-Jakob Syndrome
Vascular Dementia
Sleep Stages
Huntington Disease
Parkinson Disease
Disease Progression
Extremities

ASJC Scopus subject areas

  • Health Professions(all)

Cite this

Petit, D., Montplaisir, J., & Boeve, B. F. (2010). Alzheimer's Disease and Other Dementias. In Principles and Practice of Sleep Medicine: Fifth Edition (pp. 1038-1047). Elsevier Inc.. https://doi.org/10.1016/B978-1-4160-6645-3.00091-8

Alzheimer's Disease and Other Dementias. / Petit, Dominique; Montplaisir, Jacques; Boeve, Bradley F.

Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc., 2010. p. 1038-1047.

Research output: Chapter in Book/Report/Conference proceedingChapter

Petit, D, Montplaisir, J & Boeve, BF 2010, Alzheimer's Disease and Other Dementias. in Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc., pp. 1038-1047. https://doi.org/10.1016/B978-1-4160-6645-3.00091-8
Petit D, Montplaisir J, Boeve BF. Alzheimer's Disease and Other Dementias. In Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc. 2010. p. 1038-1047 https://doi.org/10.1016/B978-1-4160-6645-3.00091-8
Petit, Dominique ; Montplaisir, Jacques ; Boeve, Bradley F. / Alzheimer's Disease and Other Dementias. Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc., 2010. pp. 1038-1047
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