Alzheimer neurofibrillary lesions: Molecular nature and potential roles of different components

Shu hui Yen, Wan Kyng Liu, Frederick L. Hall, Shi Du Yan, David Stern, Dennis W Dickson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Neurofibrillary lesions found in Alzheimer disease (AD) are known to react with antibodies raised against different molecules. At least 20 components have been detected in neurofibrillary tangles. These components can be roughly categorized into five groups, which include structural proteins, kinases and other cytosolic enzymes, stress-related molecules, amyloid and amyloid binding proteins, and others. Among them, an abnormal form of microtubule associated protein tau, PHF-tau, is a major component of Alzheimer NFT. Kinases associated with NFT, especially those belonging to the family of proline-directed Ser/Thr kinases, are considered to be important for PHF-tau hyperphosphorylation. A potentially significant kinase is a Cdc2-related kinase, which is associated tightly with paired helical filaments, has a molecular weight of 33kDa and is different from other known Cdc2-related kinases. The possibility that some of the NFT-associated elements may play an active role in the pathogenesis of Alzheimer's disease was supported by recent studies, in which advanced glycated products and markers of oxidant stress were located in NFT. In addition, PHF-tau was found to be glycated, and in vitro glycated tau was capable of inducing oxidant stress. Further characterization of different components of NFT by biochemical and other approaches will be important for understanding the mechanisms involved in the supramolecular aggregation of PHF within NFT.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalNeurobiology of Aging
Volume16
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

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Phosphotransferases
Oxidants
Alzheimer Disease
Amyloidogenic Proteins
Neurofibrillary Tangles
Microtubule-Associated Proteins
Amyloid
Proline
Protein Kinases
Carrier Proteins
Molecular Weight
Antibodies
Enzymes

Keywords

  • Neurofibrillary lesions
  • PHF-tau

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Alzheimer neurofibrillary lesions : Molecular nature and potential roles of different components. / Yen, Shu hui; Liu, Wan Kyng; Hall, Frederick L.; Yan, Shi Du; Stern, David; Dickson, Dennis W.

In: Neurobiology of Aging, Vol. 16, No. 3, 1995, p. 381-387.

Research output: Contribution to journalArticle

Yen, Shu hui ; Liu, Wan Kyng ; Hall, Frederick L. ; Yan, Shi Du ; Stern, David ; Dickson, Dennis W. / Alzheimer neurofibrillary lesions : Molecular nature and potential roles of different components. In: Neurobiology of Aging. 1995 ; Vol. 16, No. 3. pp. 381-387.
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