Alveolar recruitment and arterial desflurane concentration during bariatric surgery

Juraj Sprung, Francis X. Whalen, Thomas Comfere, Zeljko J. Bosnjak, Zeljko Bajzer, Ognjen Gajic, Michael G. Sarr, Darrell R. Schroeder, Lavonne M. Liedl, Chetan P. Offord, David O. Warner

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

BACKGROUND:: We investigated whether reversal of intraoperative atelectasis with the lung recruitment maneuver (RM) affects desflurane arterial concentrations during bariatric surgery. METHODS:: After anesthetic induction and maintenance with propofol, patients were randomized to receive alveolar RM at intervals (RM group) or not (controls). Desflurane 6% was initiated, and rate of increase of alveolar desflurane concentration (ratio of end-expiratory to inspiratory concentrations, FA/FI) and desflurane blood concentrations were measured in both groups. Blood and end-tidal desflurane concentrations were also measured after the discontinuation of anesthesia. RESULTS:: The RM group had higher intraoperative Pao2/Fio2 compared with the control group (both, P < 0.001). During induction, the rate of increase in blood desflurane concentrations was rapid in both groups. At comparable mechanical ventilation settings, median times to achieve 0.5 mM (approximately 3%) were 2.1 and 1.59 min (P = 0.09) in the control and RM group, respectively. The times to achieve 0.7 mM (approximately 4.2%) desflurane were 15.9 and 9.3 min in the control and RM group, respectively (P = 0.08). Desflurane blood concentrations tended to be higher during the first 30 min after induction in the RM group (P = 0.066). During maintenance or emergence, the blood desflurane concentrations were not different between control and RM groups. Consequently, the time to eye opening did not differ between groups. CONCLUSION:: Although the RM during bariatric surgery represents an effective method for improving intraoperative oxygenation, it does not significantly affect the desflurane blood concentrations during anesthesia or its elimination during emergence.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalAnesthesia and analgesia
Volume108
Issue number1
DOIs
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Sprung, J., Whalen, F. X., Comfere, T., Bosnjak, Z. J., Bajzer, Z., Gajic, O., Sarr, M. G., Schroeder, D. R., Liedl, L. M., Offord, C. P., & Warner, D. O. (2009). Alveolar recruitment and arterial desflurane concentration during bariatric surgery. Anesthesia and analgesia, 108(1), 120-127. https://doi.org/10.1213/ane.0b013e31818db6c7