Alveolar microstrain and the dark side of the lung

Richard A. Oeckler, Rolf D. Hubmayr

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechanisms of injury, yet uncertainty over the topographical distribution of these mechanisms continues to fuel controversies over "best ventilation practice" in injured lungs. In this issue Pavone and colleagues have explored the temporal and spatial evolution of VALI in an elegant use of intravital microscopy. Their findings reinforce the notion that regions which receive most of the inspired gas, in Pavone's case the non-dependent lung of a rat supported in the lateral decubitus posture, are particularly susceptible to injury. However, the inability to measure tissue strain remote from the pleura keeps important questions about small scale intra-acinar stress and strain distributions unanswered.

Original languageEnglish (US)
Article number177
JournalCritical Care
Volume11
Issue number6
DOIs
StatePublished - Nov 12 2007

Fingerprint

Lung Injury
Ventilation
Lung
Pleura
Wounds and Injuries
Posture
Practice Guidelines
Artificial Respiration
Critical Illness
Uncertainty
Gases
Research
Intravital Microscopy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Medicine(all)

Cite this

Alveolar microstrain and the dark side of the lung. / Oeckler, Richard A.; Hubmayr, Rolf D.

In: Critical Care, Vol. 11, No. 6, 177, 12.11.2007.

Research output: Contribution to journalArticle

Oeckler, Richard A. ; Hubmayr, Rolf D. / Alveolar microstrain and the dark side of the lung. In: Critical Care. 2007 ; Vol. 11, No. 6.
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