Alveolar epithelial cytoskeleton and cell vulnerability to stretch

Susan S. Margulies, Jane Oswari, Michael A. Matthay, Daniel J. Tschumperlin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Two sets of experiments were performed to test the hypothesis that viability after stretch is related to the microfilament structure. To enhance cell resistance to stretch, a potent mitogen with protective effects on the alveolar epithelium was pretreated in vivo with keratinocyte growth factor (KGF). The enhancement of F-actin in concert was observed. To depolymerize F-actin, cells were pretreated with Cytochalasin D. It was determined that cell viability after cyclic stretch is compromised compared with untreated stretched cells.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages517-518
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

ASJC Scopus subject areas

  • Engineering(all)

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    Margulies, S. S., Oswari, J., Matthay, M. A., & Tschumperlin, D. J. (1999). Alveolar epithelial cytoskeleton and cell vulnerability to stretch. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 42, pp. 517-518). ASME.