TY - JOUR
T1 - Aluminum Contamination of Albumin-Replacement Solutions
AU - Loeliger, E. A.
AU - de Wolff, F. A.
AU - Milliner, Dawn S.
AU - Feldman, Fred
AU - Shinaberger, James H.
AU - Coburn, Jack W.
PY - 1985/5/23
Y1 - 1985/5/23
N2 - To the Editor: Milliner et al. (Jan. 17 issue)1 were unable to explain why commercially available albumin solutions contain large quantities of aluminum. They concluded, however, that it must be an artifact of collection, processing, or storage. We think that an observation of ours, made 15 years ago, may elucidate their observation. For decades aluminum hydroxide [Al(OH)3] gel has been used in the coagulation laboratory to absorb the vitamin K–dependent coagulation factors. By means of this principle, concentrates of the four factors can be obtained for use in clinical practice.2 However, the aluminum compound is not easily removed.
AB - To the Editor: Milliner et al. (Jan. 17 issue)1 were unable to explain why commercially available albumin solutions contain large quantities of aluminum. They concluded, however, that it must be an artifact of collection, processing, or storage. We think that an observation of ours, made 15 years ago, may elucidate their observation. For decades aluminum hydroxide [Al(OH)3] gel has been used in the coagulation laboratory to absorb the vitamin K–dependent coagulation factors. By means of this principle, concentrates of the four factors can be obtained for use in clinical practice.2 However, the aluminum compound is not easily removed.
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U2 - 10.1056/NEJM198505233122114
DO - 10.1056/NEJM198505233122114
M3 - Letter
C2 - 3990741
AN - SCOPUS:0021957144
SN - 0028-4793
VL - 312
SP - 1389
EP - 1390
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -