Altered ratios of measles virus transcripts in diseased human brains

Roberto Cattaneo, Gabriela Rebmann, Knut Baczko, Volker ter Meulen, Martin A. Billeter

Research output: Contribution to journalArticle

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Abstract

In rare cases measles virus (MV) induces subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephalitis (MIBE), two lethal diseases of the human central nervous system. MV transcripts present in the brains of two SSPE patients and one MIBE patient were analyzed by quantitative Northern blots. In all three cases the transcripts from the first MV gene were relatively abundant, amounting to about one-tenth of that in lytically infected cells. However, the quantity of transcripts decreased sharply for each subsequent MV gene, arriving at 200-fold lower levels for the fifth MV gene. In comparison gradients of transcript levels are more shallow in either lytically or persistently infected cultured cells, where the transcripts of the fifth MV gene are only about five times less abundant than those of the first. These altered ratios of mRNAs appear to be typical for persistent MV brain infections and most likely lead to reduced expression of the viral envelope proteins, encoded by distal MV genes, at the surface of brain cells. This could account for the lack of viral budding and allow persistent MV infections to elude immune surveillance.

Original languageEnglish (US)
Pages (from-to)523-526
Number of pages4
JournalVirology
Volume160
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Measles virus
Brain Diseases
Subacute Sclerosing Panencephalitis
Genes
Virus Diseases
Brain
Viral Envelope Proteins
Central Nervous System Diseases
Northern Blotting
Cultured Cells
Messenger RNA

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Cattaneo, R., Rebmann, G., Baczko, K., ter Meulen, V., & Billeter, M. A. (1987). Altered ratios of measles virus transcripts in diseased human brains. Virology, 160(2), 523-526. https://doi.org/10.1016/0042-6822(87)90031-6

Altered ratios of measles virus transcripts in diseased human brains. / Cattaneo, Roberto; Rebmann, Gabriela; Baczko, Knut; ter Meulen, Volker; Billeter, Martin A.

In: Virology, Vol. 160, No. 2, 1987, p. 523-526.

Research output: Contribution to journalArticle

Cattaneo, R, Rebmann, G, Baczko, K, ter Meulen, V & Billeter, MA 1987, 'Altered ratios of measles virus transcripts in diseased human brains', Virology, vol. 160, no. 2, pp. 523-526. https://doi.org/10.1016/0042-6822(87)90031-6
Cattaneo, Roberto ; Rebmann, Gabriela ; Baczko, Knut ; ter Meulen, Volker ; Billeter, Martin A. / Altered ratios of measles virus transcripts in diseased human brains. In: Virology. 1987 ; Vol. 160, No. 2. pp. 523-526.
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