Abstract
A novel thesis is that healthy aging of neuroendocrine axes is marked by disruption of orderly patterns of hormone release (1). This can be quantified by a recently validated approximate entropy statistic applied to 24-hour hormone profiles, e.g., luteinizing hormone (LH), and growth hormone (GH). Moreover, more subtle disturbances of feedback control are indicated by decreased conditional regularity or synchrony (higher cross-approximate entropy) within coupled axes, such as ACTH-cortisol, LH-testosterone, etc. Such alterations can precede any changes in mean serum hormone concentrations, thus highlighting an impact of age on the feedback control mechanisms that coordinate the flow of signaling information within a neuroendocrine axis or network.
Original language | English (US) |
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Pages (from-to) | 19-20 |
Number of pages | 2 |
Journal | Aging clinical and experimental research |
Volume | 9 |
Issue number | 4 SUPPL. |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology