TY - JOUR
T1 - Altered pulsatile and coordinate secretion of pituitary hormones in aging
T2 - Evidence of feedback disruption
AU - Veldhuis, J. D.
PY - 1997
Y1 - 1997
N2 - A novel thesis is that healthy aging of neuroendocrine axes is marked by disruption of orderly patterns of hormone release (1). This can be quantified by a recently validated approximate entropy statistic applied to 24-hour hormone profiles, e.g., luteinizing hormone (LH), and growth hormone (GH). Moreover, more subtle disturbances of feedback control are indicated by decreased conditional regularity or synchrony (higher cross-approximate entropy) within coupled axes, such as ACTH-cortisol, LH-testosterone, etc. Such alterations can precede any changes in mean serum hormone concentrations, thus highlighting an impact of age on the feedback control mechanisms that coordinate the flow of signaling information within a neuroendocrine axis or network.
AB - A novel thesis is that healthy aging of neuroendocrine axes is marked by disruption of orderly patterns of hormone release (1). This can be quantified by a recently validated approximate entropy statistic applied to 24-hour hormone profiles, e.g., luteinizing hormone (LH), and growth hormone (GH). Moreover, more subtle disturbances of feedback control are indicated by decreased conditional regularity or synchrony (higher cross-approximate entropy) within coupled axes, such as ACTH-cortisol, LH-testosterone, etc. Such alterations can precede any changes in mean serum hormone concentrations, thus highlighting an impact of age on the feedback control mechanisms that coordinate the flow of signaling information within a neuroendocrine axis or network.
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U2 - 10.1007/bf03339688
DO - 10.1007/bf03339688
M3 - Article
C2 - 9358867
AN - SCOPUS:0031308208
SN - 0394-9532
VL - 9
SP - 19
EP - 20
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 4 SUPPL.
ER -