Altered pulsatile and coordinate secretion of pituitary hormones in aging: Evidence of feedback disruption

J. D. Veldhuis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A novel thesis is that healthy aging of neuroendocrine axes is marked by disruption of orderly patterns of hormone release (1). This can be quantified by a recently validated approximate entropy statistic applied to 24-hour hormone profiles, e.g., luteinizing hormone (LH), and growth hormone (GH). Moreover, more subtle disturbances of feedback control are indicated by decreased conditional regularity or synchrony (higher cross-approximate entropy) within coupled axes, such as ACTH-cortisol, LH-testosterone, etc. Such alterations can precede any changes in mean serum hormone concentrations, thus highlighting an impact of age on the feedback control mechanisms that coordinate the flow of signaling information within a neuroendocrine axis or network.

Original languageEnglish (US)
Pages (from-to)19-20
Number of pages2
JournalAging Clinical and Experimental Research
Volume9
Issue number4 SUPPL.
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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