Altered cortical microarchitecture in patients with monoclonal gammopathy of undetermined significance

Joshua N. Farr, Wei Zhang, Shaji K. Kumar, Richard M. Jacques, Alvin C. Ng, Louise K. McCready, S. Vincent Rajkumar, Matthew T. Drake

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Patients with monoclonal gammopathy of undetermined significance (MGUS) are at increased fracture risk, and we have previously shown that MGUS patients have altered trabecular bone microarchitecture compared with controls. However, there are no data on whether the porosity of cortical bone, which may play a greater role in bone strength and the occurrence of fractures, is increased in MGUS. Thus, we studied cortical porosity and bone strength (apparentmodulus) using high-resolution peripheral quantitative computed tomography imaging of the distal radius in 50 MGUS patients and 100 age-, gender-, and body mass index-matched controls. Compared with controls, MGUS patients had both significantly higher cortical porosity (116.8%; P > .05) and lower apparentmodulus (-8.9%; P > .05). Despite their larger radial bone size, MGUS patients have significantly increased cortical bone porosity and reduced bone strength relative to controls. This increased cortical porosity may explain the increased fracture risk seen in MGUS patients. (Blood. 2014;123(5):647-649).

Original languageEnglish (US)
Pages (from-to)647-649
Number of pages3
JournalBlood
Volume123
Issue number5
DOIs
StatePublished - Jan 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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