Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery

H. L. Reed, B. Chernow, C. R. Lake, G. P. Zaloga, M. A. Stoiko, D. Baerdsly, D. Cruess, C. Lee, Robert Christian Smallridge

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To determine how intraoperative hypothermia associated with coronary bypass surgery (CABS) alters sympathetic nervous system (SNS) activity, we prospectively studied 21 adult CABS patients and measured preoperative, intraoperative, and postoperative circulating catecholamine concentrations. Because thyroid hormone levels change rapidly following CABS, we also serially measured these hormone levels. The measured plasma concentrations for each of the above variables were corrected for hemodilution during CABS by using serum albumin changes as a reference. It was concluded that important alterations in SNS activity and thyroid hormone homeostasis occur in humans during CABS and deep hypothermia, and that changes in core temperature may contribute to these findings. We speculate that these hormonal changes may influence the response to adrenergic receptor therapy in hypothermic patients and may contribute to arrhythmias during rewarming and the immediate postoperative period.

Original languageEnglish (US)
Pages (from-to)616-622
Number of pages7
JournalChest
Volume95
Issue number3
StatePublished - 1989
Externally publishedYes

Fingerprint

Sympathetic Nervous System
Hypothermia
Coronary Artery Bypass
Thyroid Hormones
Rewarming
Hemodilution
Postoperative Period
Serum Albumin
Adrenergic Receptors
Catecholamines
Cardiac Arrhythmias
Homeostasis
Hormones
Temperature

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Reed, H. L., Chernow, B., Lake, C. R., Zaloga, G. P., Stoiko, M. A., Baerdsly, D., ... Smallridge, R. C. (1989). Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery. Chest, 95(3), 616-622.

Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery. / Reed, H. L.; Chernow, B.; Lake, C. R.; Zaloga, G. P.; Stoiko, M. A.; Baerdsly, D.; Cruess, D.; Lee, C.; Smallridge, Robert Christian.

In: Chest, Vol. 95, No. 3, 1989, p. 616-622.

Research output: Contribution to journalArticle

Reed, HL, Chernow, B, Lake, CR, Zaloga, GP, Stoiko, MA, Baerdsly, D, Cruess, D, Lee, C & Smallridge, RC 1989, 'Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery', Chest, vol. 95, no. 3, pp. 616-622.
Reed HL, Chernow B, Lake CR, Zaloga GP, Stoiko MA, Baerdsly D et al. Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery. Chest. 1989;95(3):616-622.
Reed, H. L. ; Chernow, B. ; Lake, C. R. ; Zaloga, G. P. ; Stoiko, M. A. ; Baerdsly, D. ; Cruess, D. ; Lee, C. ; Smallridge, Robert Christian. / Alterations in sympathetic nervous system activity with intraoperative hypothermia during coronary artery bypass surgery. In: Chest. 1989 ; Vol. 95, No. 3. pp. 616-622.
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