Alterations in rat cardiac myosin isozymes induced by whole-body irradiation are prevented by 3,5,3′-l-triiodothyronine

Raye Z. Litten, Henry G. Fein, Grealon T. Gainey, Thomas L. Walden, Robert Christian Smallridge

Research output: Contribution to journalArticle

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Abstract

Changes in cardiac myosin isozymes and serum thyroid hormone levels were investigated in rats following 10 Gy whole-body gamma irradiation. The percent β-myosin heavy chain increased from 21.3 ± 1.8 to 28.1 ± 6.8 (NS) at 3-day postirradiation, 37.7 ± 1.9 (P<.001) at 6-day postirradiation, and 43.8 ± 3.3 (P<.001) at 9-day postirradiation. Along with the change in myosin isozymes was a significant 53% decrease (P<.001) in the serum thyroxine (T4) level by day 3 postirradiation, remaining depressed through day 9 postirradiation. The serum 3,5,3′-triiodothyronine (T3) level, however, was normal until day 9, when significant depression was also observed. In contrast, the thyroid-stimulating hormone (TSH) level was significantly increased by fourfold at day 3, returning to near normal values by day 9 postirradiation. Daily injections of physiological doses of T3 ( 0.3 μg 100 g body weight) prevented the change in the myosin isozymes following whole-body irradiation. Daily pharmacological injections of T3 ( 3.0 μg 100 g body weight) to the irradiated rats produced a further decrease in the percent β-myosin heavy chain (below control values) indicating tissue hyperthyroidism. Thus, this study suggests that the change in myosin isozymes following whole-body irradiation is caused by an alteration in thyroid hormone activity.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalMetabolism
Volume39
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Cardiac Myosins
Whole-Body Irradiation
Triiodothyronine
Isoenzymes
Myosins
Myosin Heavy Chains
montirelin
Thyroid Hormones
Serum
Body Weight Changes
Injections
Thyrotropin
Hyperthyroidism
Thyroxine
Reference Values
Body Weight
Pharmacology

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Alterations in rat cardiac myosin isozymes induced by whole-body irradiation are prevented by 3,5,3′-l-triiodothyronine. / Litten, Raye Z.; Fein, Henry G.; Gainey, Grealon T.; Walden, Thomas L.; Smallridge, Robert Christian.

In: Metabolism, Vol. 39, No. 1, 1990, p. 64-68.

Research output: Contribution to journalArticle

Litten, Raye Z. ; Fein, Henry G. ; Gainey, Grealon T. ; Walden, Thomas L. ; Smallridge, Robert Christian. / Alterations in rat cardiac myosin isozymes induced by whole-body irradiation are prevented by 3,5,3′-l-triiodothyronine. In: Metabolism. 1990 ; Vol. 39, No. 1. pp. 64-68.
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abstract = "Changes in cardiac myosin isozymes and serum thyroid hormone levels were investigated in rats following 10 Gy whole-body gamma irradiation. The percent β-myosin heavy chain increased from 21.3 ± 1.8 to 28.1 ± 6.8 (NS) at 3-day postirradiation, 37.7 ± 1.9 (P<.001) at 6-day postirradiation, and 43.8 ± 3.3 (P<.001) at 9-day postirradiation. Along with the change in myosin isozymes was a significant 53{\%} decrease (P<.001) in the serum thyroxine (T4) level by day 3 postirradiation, remaining depressed through day 9 postirradiation. The serum 3,5,3′-triiodothyronine (T3) level, however, was normal until day 9, when significant depression was also observed. In contrast, the thyroid-stimulating hormone (TSH) level was significantly increased by fourfold at day 3, returning to near normal values by day 9 postirradiation. Daily injections of physiological doses of T3 ( 0.3 μg 100 g body weight) prevented the change in the myosin isozymes following whole-body irradiation. Daily pharmacological injections of T3 ( 3.0 μg 100 g body weight) to the irradiated rats produced a further decrease in the percent β-myosin heavy chain (below control values) indicating tissue hyperthyroidism. Thus, this study suggests that the change in myosin isozymes following whole-body irradiation is caused by an alteration in thyroid hormone activity.",
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