Alterations in pulsatile luteinizing hormone and follicle-stimulating hormone secretion in idiopathic oligoasthenospermic men: Assessment by deconvolution analysis - A clinical research center study

A. Reyes-Fuentes, M. E. Chavarría, A. Carrera, G. Aguilera, A. Rosado, E. Samojlik, A. Iranmanesh, Johannes D Veldhuis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To investigate the nature of neuroendocrine disturbances of the hypothalamo-pituitary-gonadal axis in idiopathic male infertility, we studied 14 infertile men with oligoasthenozoospermia (OLIGO) and 15 age-, body mass index-, and community-matched euspermic controls by blood withdrawal at 10- min intervals for 12 h to encompass basal 18-h) and exogenous GnRH-stimulated (4-h) pulsatile release of LB and FSH (by immunoradiometric assay) as well as testosterone (by RIA). Deconvolution analysis was used to estimate endogenous LH and FSH half-lives, secretory burst frequency, amplitude, duration, and mass. OLIGO men exhibited normal serum concentrations of total, free, and percent dialyzable testosterone and estradiol, but distinct dynamic alterations within the LH and FSH axes; namely (P< 0.05), 1) a prolonged half-life of LH (OLIGO, 95 ± 19 min; control, 80 ± 9.3 min) and a reduced half-life of FSH (OLIGO 260 ± 79 min; control, 320 ± 93 min); 2) a low LH, but normal FSH, secretory burst frequency (OLIGO, 12 ± 3.4; control, 15 ± 3.0 LH pulses/day); 3) a decreased serum testosterone peak frequency (OLIGO, 15 ± 4.3; control, 21 ± 3.2 peaks/day); and 4) an amplified mass of LH (1.1- to 1.3-fold higher in OLIGO) and FSH (2.4- to 2.7-fold higher in OLIGO) secreted per burst basally as well as after GnRH injection. These disturbances were readily distinguishable from the neuroendocrine dysregulation described in other states of male hypogonadotropism (e.g. uremia, fasting, and aging).

Original languageEnglish (US)
Pages (from-to)524-529
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume81
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Follicle Stimulating Hormone
Deconvolution
Luteinizing Hormone
Testosterone
Gonadotropin-Releasing Hormone
Half-Life
Research
Immunoradiometric Assay
Uremia
Male Infertility
Serum
Estradiol
Fasting
Body Mass Index
Injections
Assays
Blood
Aging of materials

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Alterations in pulsatile luteinizing hormone and follicle-stimulating hormone secretion in idiopathic oligoasthenospermic men : Assessment by deconvolution analysis - A clinical research center study. / Reyes-Fuentes, A.; Chavarría, M. E.; Carrera, A.; Aguilera, G.; Rosado, A.; Samojlik, E.; Iranmanesh, A.; Veldhuis, Johannes D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 81, No. 2, 1996, p. 524-529.

Research output: Contribution to journalArticle

Reyes-Fuentes, A. ; Chavarría, M. E. ; Carrera, A. ; Aguilera, G. ; Rosado, A. ; Samojlik, E. ; Iranmanesh, A. ; Veldhuis, Johannes D. / Alterations in pulsatile luteinizing hormone and follicle-stimulating hormone secretion in idiopathic oligoasthenospermic men : Assessment by deconvolution analysis - A clinical research center study. In: Journal of Clinical Endocrinology and Metabolism. 1996 ; Vol. 81, No. 2. pp. 524-529.
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abstract = "To investigate the nature of neuroendocrine disturbances of the hypothalamo-pituitary-gonadal axis in idiopathic male infertility, we studied 14 infertile men with oligoasthenozoospermia (OLIGO) and 15 age-, body mass index-, and community-matched euspermic controls by blood withdrawal at 10- min intervals for 12 h to encompass basal 18-h) and exogenous GnRH-stimulated (4-h) pulsatile release of LB and FSH (by immunoradiometric assay) as well as testosterone (by RIA). Deconvolution analysis was used to estimate endogenous LH and FSH half-lives, secretory burst frequency, amplitude, duration, and mass. OLIGO men exhibited normal serum concentrations of total, free, and percent dialyzable testosterone and estradiol, but distinct dynamic alterations within the LH and FSH axes; namely (P< 0.05), 1) a prolonged half-life of LH (OLIGO, 95 ± 19 min; control, 80 ± 9.3 min) and a reduced half-life of FSH (OLIGO 260 ± 79 min; control, 320 ± 93 min); 2) a low LH, but normal FSH, secretory burst frequency (OLIGO, 12 ± 3.4; control, 15 ± 3.0 LH pulses/day); 3) a decreased serum testosterone peak frequency (OLIGO, 15 ± 4.3; control, 21 ± 3.2 peaks/day); and 4) an amplified mass of LH (1.1- to 1.3-fold higher in OLIGO) and FSH (2.4- to 2.7-fold higher in OLIGO) secreted per burst basally as well as after GnRH injection. These disturbances were readily distinguishable from the neuroendocrine dysregulation described in other states of male hypogonadotropism (e.g. uremia, fasting, and aging).",
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AU - Chavarría, M. E.

AU - Carrera, A.

AU - Aguilera, G.

AU - Rosado, A.

AU - Samojlik, E.

AU - Iranmanesh, A.

AU - Veldhuis, Johannes D

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