Alpha-synuclein's degradation in vivo

Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

Darius Ebrahimi-Fakhari, Pamela J McLean, Vivek K. Unni

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in α-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease.

Original languageEnglish (US)
JournalAutophagy
Volume8
Issue number2
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Synucleins
alpha-Synuclein
Parkinson Disease
Lewy Body Disease
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Neurodegenerative Diseases
Proteolysis
Pathology
Proteins

Keywords

  • α-synuclein
  • Autophagy
  • Degradation
  • In vivo
  • Lewy bodies
  • Lysosome
  • Multiphoton imaging
  • Neurodegeneration
  • Parkinson disease
  • Proteasome

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Alpha-synuclein's degradation in vivo : Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease. / Ebrahimi-Fakhari, Darius; McLean, Pamela J; Unni, Vivek K.

In: Autophagy, Vol. 8, No. 2, 02.2012.

Research output: Contribution to journalArticle

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