Alpha-synuclein repeat variants and survival in parkinson's disease

Sun Ju Chung, Joanna M. Biernacka, Sebastian M. Armasu, Kari Anderson, Roberta Frigerio, Jan O. Aasly, Grazia Annesi, Anna Rita Bentivoglio, Laura Brighina, Marie Christine Chartier-Harlin, Stefano Goldwurm, Georgios Hadjigeorgiou, Barbara Jasinska-Myga, Beom Seok Jeon, Yun Joong Kim, Rejko Krüger, Suzanne Lesage, Katerina Markopoulou, George Mellick, Karen E. MorrisonAndreas Puschmann, Eng King Tan, David Crosiers, Jessie Theuns, Christine Van Broeckhoven, Karin Wirdefeldt, Zbigniew K. Wszolek, Alexis Elbaz, Demetrius M. Maraganore, Gilad Yahalom, Yael Orlev, Oren S. Cohen, Evgenia Kozlova, Eitan Friedman, Rivka Inzelberg, Sharon Hassin-Baer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

Original languageEnglish (US)
Pages (from-to)1053-1057
Number of pages5
JournalMovement Disorders
Volume29
Issue number8
DOIs
StatePublished - Jul 2014

Keywords

  • Association
  • Gene
  • Parkinson's disease
  • Survival
  • α-synuclein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Chung, S. J., Biernacka, J. M., Armasu, S. M., Anderson, K., Frigerio, R., Aasly, J. O., Annesi, G., Bentivoglio, A. R., Brighina, L., Chartier-Harlin, M. C., Goldwurm, S., Hadjigeorgiou, G., Jasinska-Myga, B., Jeon, B. S., Kim, Y. J., Krüger, R., Lesage, S., Markopoulou, K., Mellick, G., ... Hassin-Baer, S. (2014). Alpha-synuclein repeat variants and survival in parkinson's disease. Movement Disorders, 29(8), 1053-1057. https://doi.org/10.1002/mds.25841