Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Alex Rajput, Carles Vilariño-Güell, Michele L. Rajput, Owen A Ross, Alexandra I. Soto-Ortolaza, Sarah J. Lincoln, Stephanie A. Cobb, Michael G. Heckman, Matthew J. Farrer, Ali Rajput

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

Original languageEnglish (US)
Pages (from-to)2411-2414
Number of pages4
JournalMovement Disorders
Volume24
Issue number16
DOIs
StatePublished - Dec 15 2009

Fingerprint

Saskatchewan
alpha-Synuclein
Parkinson Disease
Population
Mutation
Parkinsonian Disorders
Age of Onset
Disease Progression
Alleles
Genes

Keywords

  • Alpha-synuclein
  • Genetics
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Rajput, A., Vilariño-Güell, C., Rajput, M. L., Ross, O. A., Soto-Ortolaza, A. I., Lincoln, S. J., ... Rajput, A. (2009). Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. Movement Disorders, 24(16), 2411-2414. https://doi.org/10.1002/mds.22795

Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. / Rajput, Alex; Vilariño-Güell, Carles; Rajput, Michele L.; Ross, Owen A; Soto-Ortolaza, Alexandra I.; Lincoln, Sarah J.; Cobb, Stephanie A.; Heckman, Michael G.; Farrer, Matthew J.; Rajput, Ali.

In: Movement Disorders, Vol. 24, No. 16, 15.12.2009, p. 2411-2414.

Research output: Contribution to journalArticle

Rajput, A, Vilariño-Güell, C, Rajput, ML, Ross, OA, Soto-Ortolaza, AI, Lincoln, SJ, Cobb, SA, Heckman, MG, Farrer, MJ & Rajput, A 2009, 'Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population', Movement Disorders, vol. 24, no. 16, pp. 2411-2414. https://doi.org/10.1002/mds.22795
Rajput A, Vilariño-Güell C, Rajput ML, Ross OA, Soto-Ortolaza AI, Lincoln SJ et al. Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. Movement Disorders. 2009 Dec 15;24(16):2411-2414. https://doi.org/10.1002/mds.22795
Rajput, Alex ; Vilariño-Güell, Carles ; Rajput, Michele L. ; Ross, Owen A ; Soto-Ortolaza, Alexandra I. ; Lincoln, Sarah J. ; Cobb, Stephanie A. ; Heckman, Michael G. ; Farrer, Matthew J. ; Rajput, Ali. / Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. In: Movement Disorders. 2009 ; Vol. 24, No. 16. pp. 2411-2414.
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