Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Alex Rajput, Carles Vilariño-Güell, Michele L. Rajput, Owen A. Ross, Alexandra I. Soto-Ortolaza, Sarah J. Lincoln, Stephanie A. Cobb, Michael G. Heckman, Matthew J. Farrer, Ali Rajput

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

Original languageEnglish (US)
Pages (from-to)2411-2414
Number of pages4
JournalMovement Disorders
Volume24
Issue number16
DOIs
StatePublished - Dec 15 2009

Keywords

  • Alpha-synuclein
  • Genetics
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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