Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Alex Rajput; Carles Vilariño-Güell; Michele L. Rajput; Owen A. Ross; Alexandra I. Soto-Ortolaza; Sarah J. Lincoln; Stephanie A. Cobb; Michael G. Heckman; Matthew J. Farrer; Ali Rajput

doi:10.1002/mds.22795

Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Alex Rajput, Carles Vilariño-Güell, Michele L. Rajput, Owen A. Ross, Alexandra I. Soto-Ortolaza, Sarah J. Lincoln, Stephanie A. Cobb, Michael G. Heckman, Matthew J. Farrer, Ali Rajput

Neuroscience

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

Original language	English (US)
Pages (from-to)	2411-2414
Number of pages	4
Journal	Movement Disorders
Volume	24
Issue number	16
DOIs	https://doi.org/10.1002/mds.22795
State	Published - Dec 15 2009

Keywords

Alpha-synuclein
Genetics
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.22795

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title = "Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population",

abstract = "Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele {"}G{"} at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.",

keywords = "Alpha-synuclein, Genetics, Parkinson's disease",

author = "Alex Rajput and Carles Vilari{\~n}o-G{\"u}ell and Rajput, {Michele L.} and Ross, {Owen A.} and Soto-Ortolaza, {Alexandra I.} and Lincoln, {Sarah J.} and Cobb, {Stephanie A.} and Heckman, {Michael G.} and Farrer, {Matthew J.} and Ali Rajput",

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T1 - Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

AU - Rajput, Alex

AU - Vilariño-Güell, Carles

AU - Rajput, Michele L.

AU - Ross, Owen A.

AU - Soto-Ortolaza, Alexandra I.

AU - Lincoln, Sarah J.

AU - Cobb, Stephanie A.

AU - Heckman, Michael G.

AU - Farrer, Matthew J.

AU - Rajput, Ali

PY - 2009/12/15

Y1 - 2009/12/15

N2 - Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

AB - Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.

KW - Alpha-synuclein

KW - Genetics

KW - Parkinson's disease

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Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population

Abstract

Keywords

ASJC Scopus subject areas

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