Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease

Kevin J. Klos, Keith A. Josephs, Joseph E. Parisi, Dennis W. Dickson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.

Original languageEnglish (US)
Pages (from-to)1515-1520
Number of pages6
JournalMovement Disorders
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2005

Keywords

  • Argyrophilic grain disease
  • Lewy bodies
  • Motor neuron disease
  • Sporadic idiopathic Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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