Abstract
A deficiency of α1-antitrypsin has been implicated in the development of arterial aneurysms, including intracranial aneurysms. The authors determined the prevalence of α1-antitrypsin deficiency of different phenotypes in 100 consecutive patients with intracranial aneurysms and compared the distribution of α1-antitrypsin phenotypes to that in the general population (904 people). The study population consisted of 44 men and 56 women with a mean age of 52 years (range 15-81 years). The heterozygous α1-antitrypsin deficiency states (PiMS and PiMZ) were more common in patients (16%) than in the general population (7%), providing an odds ratio of 2.56 (95% confidence interval (CI) 1.32-4.75; po = 0.005). In addition, one patient (1%) was homozygous for the deficient allele (PiZZ) compared to an expected number of 0.015, providing an odds ratio of 67.0 (95% CI 2.0-363.3; p = 0.015). These findings lead the authors to suggest that the heterozygous and homozygous α1-antitrypsin deficiency states are genetic risk factors for the development of intracranial aneurysms.
Original language | English (US) |
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Pages (from-to) | 781-784 |
Number of pages | 4 |
Journal | Journal of neurosurgery |
Volume | 84 |
Issue number | 5 |
DOIs | |
State | Published - May 1996 |
Keywords
- alpha-1-antitrypsin deficiency
- cerebral aneurysm
- genetics
- subarachnoid hemorrhage
ASJC Scopus subject areas
- Surgery
- Clinical Neurology