Abstract
A deficiency of α1-antitrypsin has been implicated in the development of arterial aneurysms, including intracranial aneurysms. The authors determined the prevalence of α1-antitrypsin deficiency of different phenotypes in 100 consecutive patients with intracranial aneurysms and compared the distribution of α1-antitrypsin phenotypes to that in the general population (904 people). The study population consisted of 44 men and 56 women with a mean age of 52 years (range 15-81 years). The heterozygous α1-antitrypsin deficiency states (PiMS and PiMZ) were more common in patients (16%) than in the general population (7%), providing an odds ratio of 2.56 (95% confidence interval (CI) 1.32-4.75; po = 0.005). In addition, one patient (1%) was homozygous for the deficient allele (PiZZ) compared to an expected number of 0.015, providing an odds ratio of 67.0 (95% CI 2.0-363.3; p = 0.015). These findings lead the authors to suggest that the heterozygous and homozygous α1-antitrypsin deficiency states are genetic risk factors for the development of intracranial aneurysms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 781-784 |
| Number of pages | 4 |
| Journal | Journal of Neurosurgery |
| Volume | 84 |
| Issue number | 5 |
| State | Published - May 1996 |
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Keywords
- alpha-1-antitrypsin deficiency
- cerebral aneurysm
- genetics
- subarachnoid hemorrhage
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms. / Schievink, Wouter I.; Katzmann, Jerry A.; Piepgras, David G.; Schaid, Daniel J.
In: Journal of Neurosurgery, Vol. 84, No. 5, 05.1996, p. 781-784.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms
AU - Schievink, Wouter I.
AU - Katzmann, Jerry A.
AU - Piepgras, David G.
AU - Schaid, Daniel J
PY - 1996/5
Y1 - 1996/5
N2 - A deficiency of α1-antitrypsin has been implicated in the development of arterial aneurysms, including intracranial aneurysms. The authors determined the prevalence of α1-antitrypsin deficiency of different phenotypes in 100 consecutive patients with intracranial aneurysms and compared the distribution of α1-antitrypsin phenotypes to that in the general population (904 people). The study population consisted of 44 men and 56 women with a mean age of 52 years (range 15-81 years). The heterozygous α1-antitrypsin deficiency states (PiMS and PiMZ) were more common in patients (16%) than in the general population (7%), providing an odds ratio of 2.56 (95% confidence interval (CI) 1.32-4.75; po = 0.005). In addition, one patient (1%) was homozygous for the deficient allele (PiZZ) compared to an expected number of 0.015, providing an odds ratio of 67.0 (95% CI 2.0-363.3; p = 0.015). These findings lead the authors to suggest that the heterozygous and homozygous α1-antitrypsin deficiency states are genetic risk factors for the development of intracranial aneurysms.
AB - A deficiency of α1-antitrypsin has been implicated in the development of arterial aneurysms, including intracranial aneurysms. The authors determined the prevalence of α1-antitrypsin deficiency of different phenotypes in 100 consecutive patients with intracranial aneurysms and compared the distribution of α1-antitrypsin phenotypes to that in the general population (904 people). The study population consisted of 44 men and 56 women with a mean age of 52 years (range 15-81 years). The heterozygous α1-antitrypsin deficiency states (PiMS and PiMZ) were more common in patients (16%) than in the general population (7%), providing an odds ratio of 2.56 (95% confidence interval (CI) 1.32-4.75; po = 0.005). In addition, one patient (1%) was homozygous for the deficient allele (PiZZ) compared to an expected number of 0.015, providing an odds ratio of 67.0 (95% CI 2.0-363.3; p = 0.015). These findings lead the authors to suggest that the heterozygous and homozygous α1-antitrypsin deficiency states are genetic risk factors for the development of intracranial aneurysms.
KW - alpha-1-antitrypsin deficiency
KW - cerebral aneurysm
KW - genetics
KW - subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=0029944627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029944627&partnerID=8YFLogxK
M3 - Article
C2 - 8622151
AN - SCOPUS:0029944627
VL - 84
SP - 781
EP - 784
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 5
ER -