Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms

Wouter I. Schievink, Jerry A. Katzmann, David G. Piepgras, Daniel J Schaid

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

A deficiency of α1-antitrypsin has been implicated in the development of arterial aneurysms, including intracranial aneurysms. The authors determined the prevalence of α1-antitrypsin deficiency of different phenotypes in 100 consecutive patients with intracranial aneurysms and compared the distribution of α1-antitrypsin phenotypes to that in the general population (904 people). The study population consisted of 44 men and 56 women with a mean age of 52 years (range 15-81 years). The heterozygous α1-antitrypsin deficiency states (PiMS and PiMZ) were more common in patients (16%) than in the general population (7%), providing an odds ratio of 2.56 (95% confidence interval (CI) 1.32-4.75; po = 0.005). In addition, one patient (1%) was homozygous for the deficient allele (PiZZ) compared to an expected number of 0.015, providing an odds ratio of 67.0 (95% CI 2.0-363.3; p = 0.015). These findings lead the authors to suggest that the heterozygous and homozygous α1-antitrypsin deficiency states are genetic risk factors for the development of intracranial aneurysms.

Original languageEnglish (US)
Pages (from-to)781-784
Number of pages4
JournalJournal of Neurosurgery
Volume84
Issue number5
StatePublished - May 1996

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alpha 1-Antitrypsin
Intracranial Aneurysm
Phenotype
Odds Ratio
Confidence Intervals
Population
Aneurysm
Alleles

Keywords

  • alpha-1-antitrypsin deficiency
  • cerebral aneurysm
  • genetics
  • subarachnoid hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schievink, W. I., Katzmann, J. A., Piepgras, D. G., & Schaid, D. J. (1996). Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms. Journal of Neurosurgery, 84(5), 781-784.

Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms. / Schievink, Wouter I.; Katzmann, Jerry A.; Piepgras, David G.; Schaid, Daniel J.

In: Journal of Neurosurgery, Vol. 84, No. 5, 05.1996, p. 781-784.

Research output: Contribution to journalArticle

Schievink, WI, Katzmann, JA, Piepgras, DG & Schaid, DJ 1996, 'Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms', Journal of Neurosurgery, vol. 84, no. 5, pp. 781-784.
Schievink, Wouter I. ; Katzmann, Jerry A. ; Piepgras, David G. ; Schaid, Daniel J. / Alpha-1-antitrypsin phenotypes among patients with intracranial aneurysms. In: Journal of Neurosurgery. 1996 ; Vol. 84, No. 5. pp. 781-784.
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