TY - JOUR
T1 - Alpha-1 adrenergic control of the venous circulation in intact dogs
AU - Appleton, C.
AU - Olajos, M.
AU - Morkin, E.
AU - Goldman, S.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - To study alpha adrenergic control of the venous circulation, 17 dogs were lightly sedated and instrumented with thermodilution pulmonary flow and aortic catheters. Hemodynamics, cardiac output and central blood volume were measured at rest. Mean circulatory filling pressure, pressure gradient for venous return and resistance to venous return were calculated from pressures obtained during transient acetylcholine-induced circulatory arrest. Phenylephrine was then infused at two steady-state levels to increase mean aortic pressures by 50 and 100% above control values. Heart rate was controlled with atropine. Phenylephrine increased (P < .025) mean aortic pressure from 80.7 ± 2.9 to 121.3 ± 7.6 to 164.7 ± 6.1 mm Hg and systemic vascular resistance from 23.3 ± 2.0 to 32.2 ± 3.5 to 43.5 ± 4.1 mm Hg/min/ml and did not change cardiac output (161.9 ± 12.6 - 175.6 ± 13.8 - 169.6 ± 11.9 ml/min/kg). Mean circulatory filling pressure increased from 7.1 ± 0.5 to 9.7 ± 0.6 to 13.2 ± 1.3 mm Hg (P < .025). Pressure gradient for venous return increased from 6.4 ± 0.4 to 7.7 ± 0.4 to 8.9 ± 0.4 mm Hg (P < .025). Central blood volume increased from 16.2 ± 0.9 to 19.4 ± 1.4 to 22.0 ± 1.9 ml/kg (P < .025). To eliminate reflex changes in vascular tone, eight dogs received ganglionic blockade with trimethaphan. After ganglionic blockade phenylephrine increased cardiac output, systemic vascular resistance, mean circulatory filling pressure, pressure gradient for venous return and central blood volume (P < .025). Thus, in conscious dogs, phenylephrine reduces peripheral vascular capacitance and shifts blood from the venous circulation to the central and arterial vascular compartments.
AB - To study alpha adrenergic control of the venous circulation, 17 dogs were lightly sedated and instrumented with thermodilution pulmonary flow and aortic catheters. Hemodynamics, cardiac output and central blood volume were measured at rest. Mean circulatory filling pressure, pressure gradient for venous return and resistance to venous return were calculated from pressures obtained during transient acetylcholine-induced circulatory arrest. Phenylephrine was then infused at two steady-state levels to increase mean aortic pressures by 50 and 100% above control values. Heart rate was controlled with atropine. Phenylephrine increased (P < .025) mean aortic pressure from 80.7 ± 2.9 to 121.3 ± 7.6 to 164.7 ± 6.1 mm Hg and systemic vascular resistance from 23.3 ± 2.0 to 32.2 ± 3.5 to 43.5 ± 4.1 mm Hg/min/ml and did not change cardiac output (161.9 ± 12.6 - 175.6 ± 13.8 - 169.6 ± 11.9 ml/min/kg). Mean circulatory filling pressure increased from 7.1 ± 0.5 to 9.7 ± 0.6 to 13.2 ± 1.3 mm Hg (P < .025). Pressure gradient for venous return increased from 6.4 ± 0.4 to 7.7 ± 0.4 to 8.9 ± 0.4 mm Hg (P < .025). Central blood volume increased from 16.2 ± 0.9 to 19.4 ± 1.4 to 22.0 ± 1.9 ml/kg (P < .025). To eliminate reflex changes in vascular tone, eight dogs received ganglionic blockade with trimethaphan. After ganglionic blockade phenylephrine increased cardiac output, systemic vascular resistance, mean circulatory filling pressure, pressure gradient for venous return and central blood volume (P < .025). Thus, in conscious dogs, phenylephrine reduces peripheral vascular capacitance and shifts blood from the venous circulation to the central and arterial vascular compartments.
UR - http://www.scopus.com/inward/record.url?scp=0022264028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022264028&partnerID=8YFLogxK
M3 - Article
C2 - 2861278
AN - SCOPUS:0022264028
SN - 0022-3565
VL - 233
SP - 729
EP - 734
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 3
ER -