Alosetron: An effective treatment for diarrhea-predominant irritable bowel syndrome

Lucinda A. Harris, Lin Chang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Serotonin (5-HT) is one of the key mediators of gut motility, secretion and sensation. Most 5-HT is localized in the gastrointestinal tract. Particularly important for gut function and regulation are the 5-HT1p, 5-HT3 and 5-HT4 receptors. These receptors have been the focus of research evaluating the pathophysiologic mechanisms of irritable bowel syndrome (IBS) as well as targets for the development of novel agents to treat irritable bowel syndrome. Alosetron is one of three 5-HT3 antagonists currently available. The other two, ondansetron and granisetron, are primarily used in the treatment of chemotherapy-induced nausea and vomiting. Alosetron, which slows gut transit, has been approved for the treatment of severe diarrhea-predominant IBS (IBS-D) in women. This review will examine the common, yet therapeutically challenging, disorder IBS, as well as the role of alosetron in the treatment of IBS-D.

Original languageEnglish (US)
Pages (from-to)15-27
Number of pages13
JournalWomen's Health
Volume3
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • 5-HT3-antagonists
  • Alosetron
  • Irritable bowel syndrome

ASJC Scopus subject areas

  • Medicine(all)

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