Allopurinol mouthwash kinetic and stability information based on normal volunteers

C. L. Loprinzi, N. L. Burnham, M. J. O'Connell, P. A. Svingen, D. A. Peterson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Oral mucositis can be a major dose-limiting toxicity of fluorouracil. An encouraging early report suggested that an allopurinol mouthwash can ameliorate fluorouracil induced mucositis. Prior to testing this concept in a randomized, double-blinded clinical trial, we investigated whether there was any appreciable systemic absorption of allopurinol when used as a mouthwash. We did not detect any evidence of systemic allopurinol in 10 normal volunteers who were administered multiple small doses of allopurinol as a mouthwash. Additionally, we determined that the allopurinol mouthwash solution is stable after storage at room temperature or refrigeration for at least 8 months.

Original languageEnglish (US)
Pages (from-to)353-354+373
JournalHospital Pharmacy
Volume24
Issue number5
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pharmacy
  • Pharmacology
  • Pharmacology (medical)

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    Loprinzi, C. L., Burnham, N. L., O'Connell, M. J., Svingen, P. A., & Peterson, D. A. (1989). Allopurinol mouthwash kinetic and stability information based on normal volunteers. Hospital Pharmacy, 24(5), 353-354+373.