TY - JOUR
T1 - Allo-SCT for myelofibrosis
T2 - Reversing the chronic phase in the JAK inhibitor era¿
AU - Tamari, R.
AU - Mughal, T. I.
AU - Rondelli, D.
AU - Hasserjian, R.
AU - Gupta, V.
AU - Odenike, O.
AU - Fauble, V.
AU - Finazzi, G.
AU - Pane, F.
AU - Mascarenhas, J.
AU - Prchal, J.
AU - Giralt, S.
AU - Hoffman, R.
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited.
PY - 2015/5/8
Y1 - 2015/5/8
N2 - At present, allo-SCT is the only curative treatment for patients with myelofibrosis (MF). Unfortunately, a significant proportion of candidate patients are considered transplant ineligible due to their poor general condition and advanced age at the time of diagnosis. The approval of the first JAK inhibitor, ruxolitinib, for patients with advanced MF in 2011 has had a qualified impact on the treatment algorithm. The drug affords substantial improvement in MF-associated symptoms and splenomegaly but no major effect on the natural history. There has, therefore, been considerable support for assessing the drug's candidacy in the peritransplant period. The drug's precise impact on clinical outcome following allo-SCT is currently not known; nor are the drug's long-term efficacy and safety known. Considering the rarity of MF and the small proportion of patients who undergo allo-SCT, well designed collaborative efforts are required. In order to address some of the principal challenges, an expert panel of laboratory and clinical experts in this field was established, and an independent workshop held during the 54th American Society of Hematology Annual Meeting in New Orleans, USA on 6 December 2013, and the European Hematology Association's Annual Meeting in Milan, Italy on 13 June 2014. This document summarizes the results of these efforts.
AB - At present, allo-SCT is the only curative treatment for patients with myelofibrosis (MF). Unfortunately, a significant proportion of candidate patients are considered transplant ineligible due to their poor general condition and advanced age at the time of diagnosis. The approval of the first JAK inhibitor, ruxolitinib, for patients with advanced MF in 2011 has had a qualified impact on the treatment algorithm. The drug affords substantial improvement in MF-associated symptoms and splenomegaly but no major effect on the natural history. There has, therefore, been considerable support for assessing the drug's candidacy in the peritransplant period. The drug's precise impact on clinical outcome following allo-SCT is currently not known; nor are the drug's long-term efficacy and safety known. Considering the rarity of MF and the small proportion of patients who undergo allo-SCT, well designed collaborative efforts are required. In order to address some of the principal challenges, an expert panel of laboratory and clinical experts in this field was established, and an independent workshop held during the 54th American Society of Hematology Annual Meeting in New Orleans, USA on 6 December 2013, and the European Hematology Association's Annual Meeting in Milan, Italy on 13 June 2014. This document summarizes the results of these efforts.
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U2 - 10.1038/bmt.2014.323
DO - 10.1038/bmt.2014.323
M3 - Review article
AN - SCOPUS:84928927817
SN - 0268-3369
VL - 50
SP - 628
EP - 636
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 5
ER -