Allergies and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer case-control consortium

Sara H. Olson, Meier Hsu, Jaya M. Satagopan, Patrick Maisonneuve, Debra T. Silverman, Ersilia Lucenteforte, Kristin E. Anderson, Ayelet Borgida, Paige M. Bracci, H. Bas Bueno-De-Mesquita, Michelle Cotterchio, Qi Dai, Eric J. Duell, Elizabeth H. Fontham, Steven Gallinger, Elizabeth A. Holly, Bu Tian Ji, Robert C. Kurtz, Carlo La Vecchia, Albert B. LowenfelsBrian Luckett, Emmy Ludwig, Gloria M Petersen, Jerry Polesel, Daniela Seminara, Lori Strayer, Renato Talamini

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31 Citations (Scopus)

Abstract

In order to quantify the risk of pancreatic cancer associated with history of any allergy and specific allergies, to investigate differences in the association with risk according to age, gender, smoking status, or body mass index, and to study the influence of age at onset, we pooled data from 10 case-control studies. In total, there were 3,567 cases and 9,145 controls. Study-specific odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression adjusted for age, gender, smoking status, and body mass index. Between-study heterogeneity was assessed by using the Cochran Q statistic. Study-specific odds ratios were pooled by using a random-effects model. The odds ratio for any allergy was 0.79 (95% confidence interval (CI): 0.62, 1.00) with heterogeneity among studies (P < 0.001). Heterogeneity was attributable to one study; with that study excluded, the pooled odds ratio was 0.73 (95% CI: 0.64, 0.84) (Pheterogeneity = 0.23). Hay fever (odds ratio = 0.74, 95% CI: 0.56, 0.96) and allergy to animals (odds ratio = 0.62, 95% CI: 0.41, 0.94) were related to lower risk, while there was no statistically significant association with other allergies or asthma. There were no major differences among subgroups defined by age, gender, smoking status, or body mass index. Older age at onset of allergies was slightly more protective than earlier age.

Original languageEnglish (US)
Pages (from-to)691-700
Number of pages10
JournalAmerican Journal of Epidemiology
Volume178
Issue number5
DOIs
StatePublished - Sep 1 2013

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Pancreatic Neoplasms
Hypersensitivity
Odds Ratio
Confidence Intervals
Body Mass Index
Smoking
Age of Onset
Seasonal Allergic Rhinitis
Case-Control Studies
Asthma
Logistic Models

Keywords

  • allergic rhinitis
  • case-control studies
  • hypersensitivity
  • pancreatic neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Olson, S. H., Hsu, M., Satagopan, J. M., Maisonneuve, P., Silverman, D. T., Lucenteforte, E., ... Talamini, R. (2013). Allergies and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer case-control consortium. American Journal of Epidemiology, 178(5), 691-700. https://doi.org/10.1093/aje/kwt052

Allergies and risk of pancreatic cancer : A pooled analysis from the pancreatic cancer case-control consortium. / Olson, Sara H.; Hsu, Meier; Satagopan, Jaya M.; Maisonneuve, Patrick; Silverman, Debra T.; Lucenteforte, Ersilia; Anderson, Kristin E.; Borgida, Ayelet; Bracci, Paige M.; Bueno-De-Mesquita, H. Bas; Cotterchio, Michelle; Dai, Qi; Duell, Eric J.; Fontham, Elizabeth H.; Gallinger, Steven; Holly, Elizabeth A.; Ji, Bu Tian; Kurtz, Robert C.; La Vecchia, Carlo; Lowenfels, Albert B.; Luckett, Brian; Ludwig, Emmy; Petersen, Gloria M; Polesel, Jerry; Seminara, Daniela; Strayer, Lori; Talamini, Renato.

In: American Journal of Epidemiology, Vol. 178, No. 5, 01.09.2013, p. 691-700.

Research output: Contribution to journalArticle

Olson, SH, Hsu, M, Satagopan, JM, Maisonneuve, P, Silverman, DT, Lucenteforte, E, Anderson, KE, Borgida, A, Bracci, PM, Bueno-De-Mesquita, HB, Cotterchio, M, Dai, Q, Duell, EJ, Fontham, EH, Gallinger, S, Holly, EA, Ji, BT, Kurtz, RC, La Vecchia, C, Lowenfels, AB, Luckett, B, Ludwig, E, Petersen, GM, Polesel, J, Seminara, D, Strayer, L & Talamini, R 2013, 'Allergies and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer case-control consortium', American Journal of Epidemiology, vol. 178, no. 5, pp. 691-700. https://doi.org/10.1093/aje/kwt052
Olson, Sara H. ; Hsu, Meier ; Satagopan, Jaya M. ; Maisonneuve, Patrick ; Silverman, Debra T. ; Lucenteforte, Ersilia ; Anderson, Kristin E. ; Borgida, Ayelet ; Bracci, Paige M. ; Bueno-De-Mesquita, H. Bas ; Cotterchio, Michelle ; Dai, Qi ; Duell, Eric J. ; Fontham, Elizabeth H. ; Gallinger, Steven ; Holly, Elizabeth A. ; Ji, Bu Tian ; Kurtz, Robert C. ; La Vecchia, Carlo ; Lowenfels, Albert B. ; Luckett, Brian ; Ludwig, Emmy ; Petersen, Gloria M ; Polesel, Jerry ; Seminara, Daniela ; Strayer, Lori ; Talamini, Renato. / Allergies and risk of pancreatic cancer : A pooled analysis from the pancreatic cancer case-control consortium. In: American Journal of Epidemiology. 2013 ; Vol. 178, No. 5. pp. 691-700.
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