All roads lead to chromatin: Multiple pathways for histone deposition

Qing Li, Rebecca Burgess, Zhiguo Zhang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chromatin, a complex of DNA and associated proteins, governs diverse processes including gene transcription, DNA replication and DNA repair. The fundamental unit of chromatin is the nucleosome, consisting of 147bp of DNA wound about 1.6 turns around a histone octamer of one (H3-H4)2 tetramer and two H2A-H2B dimers. In order to form nucleosomes, (H3-H4)2 tetramers are deposited first, followed by the rapid deposition of H2A-H2B. It is believed that the assembly of (H3-H4)2 tetramers into nucleosomes is the rate-limiting step of nucleosome assembly. Moreover, assembly of H3-H4 into nucleosomes following DNA replication, DNA repair and gene transcription is likely to be a key step in the inheritance of epigenetic information and maintenance of genome integrity. In this review, we discuss how nucleosome assembly of H3-H4 is regulated by concerted actions of histone chaperones and modifications on newly synthesized H3 and H4. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1819
Issue number3-4
DOIs
StatePublished - Mar 2012

Fingerprint

Nucleosomes
Histones
Chromatin
DNA
Histone Chaperones
Genes
Transcription
DNA Replication
DNA Repair
Repair
Histone Code
Chromatin Assembly and Disassembly
Epigenomics
Dimers
Maintenance
Genome
Wounds and Injuries
Proteins

Keywords

  • CAF-1
  • HIRA
  • Histone chaperone
  • Histone modification
  • Nucleosome assembly
  • Rtt106

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

All roads lead to chromatin : Multiple pathways for histone deposition. / Li, Qing; Burgess, Rebecca; Zhang, Zhiguo.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1819, No. 3-4, 03.2012, p. 238-246.

Research output: Contribution to journalArticle

Li, Qing ; Burgess, Rebecca ; Zhang, Zhiguo. / All roads lead to chromatin : Multiple pathways for histone deposition. In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2012 ; Vol. 1819, No. 3-4. pp. 238-246.
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