TY - JOUR
T1 - All roads lead to chromatin
T2 - Multiple pathways for histone deposition
AU - Li, Qing
AU - Burgess, Rebecca
AU - Zhang, Zhiguo
N1 - Funding Information:
This work is supported by NIH grants to ZZ. ZZ is a scholar of the Leukemia and Lymphoma Society. RB is supported by an American Heart Association Predoctoral Fellowship . We apologize to those whose publications have not been cited in this review.
PY - 2012/3
Y1 - 2012/3
N2 - Chromatin, a complex of DNA and associated proteins, governs diverse processes including gene transcription, DNA replication and DNA repair. The fundamental unit of chromatin is the nucleosome, consisting of 147bp of DNA wound about 1.6 turns around a histone octamer of one (H3-H4)2 tetramer and two H2A-H2B dimers. In order to form nucleosomes, (H3-H4)2 tetramers are deposited first, followed by the rapid deposition of H2A-H2B. It is believed that the assembly of (H3-H4)2 tetramers into nucleosomes is the rate-limiting step of nucleosome assembly. Moreover, assembly of H3-H4 into nucleosomes following DNA replication, DNA repair and gene transcription is likely to be a key step in the inheritance of epigenetic information and maintenance of genome integrity. In this review, we discuss how nucleosome assembly of H3-H4 is regulated by concerted actions of histone chaperones and modifications on newly synthesized H3 and H4. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
AB - Chromatin, a complex of DNA and associated proteins, governs diverse processes including gene transcription, DNA replication and DNA repair. The fundamental unit of chromatin is the nucleosome, consisting of 147bp of DNA wound about 1.6 turns around a histone octamer of one (H3-H4)2 tetramer and two H2A-H2B dimers. In order to form nucleosomes, (H3-H4)2 tetramers are deposited first, followed by the rapid deposition of H2A-H2B. It is believed that the assembly of (H3-H4)2 tetramers into nucleosomes is the rate-limiting step of nucleosome assembly. Moreover, assembly of H3-H4 into nucleosomes following DNA replication, DNA repair and gene transcription is likely to be a key step in the inheritance of epigenetic information and maintenance of genome integrity. In this review, we discuss how nucleosome assembly of H3-H4 is regulated by concerted actions of histone chaperones and modifications on newly synthesized H3 and H4. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
KW - CAF-1
KW - HIRA
KW - Histone chaperone
KW - Histone modification
KW - Nucleosome assembly
KW - Rtt106
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U2 - 10.1016/j.bbagrm.2011.06.013
DO - 10.1016/j.bbagrm.2011.06.013
M3 - Review article
C2 - 24459726
AN - SCOPUS:84857112310
SN - 1874-9399
VL - 1819
SP - 238
EP - 246
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 3-4
ER -