TY - JOUR
T1 - All Lactase Preparations Are Not the Same
T2 - Results of a Prospective, Randomized, Placebo‐Controlled Trial
AU - Ramirez, Francisco C.
AU - Lee, Kelvin
AU - Graham, David Y.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994/4
Y1 - 1994/4
N2 - Objective: To compare the efficacy of three commercially available oral lactase preparations in adults with lactose intolerance. Methods: Design—Prospective, randomized, placebo‐controlled trial. Setting—Outpatient study in a General Clinical Research Center. Subjects—Ten lactose‐intolerant healthy volunteers were challenged with ice cream containing 18 g of lactose. Lactase or placebo was given immediately prior to challenge. Measurements—Symptoms and breath hydrogen excretion were recorded for 3 h following lactose challenge. Results: The three products differed in their abilities to influence symptoms and breath hydrogen excretion. Only Lactaid reduced the breath hydrogen excretion with lactose (mean peak, area under the curve and cumulative breath hydrogen excretion) (P < 0.05). Lactrase and Dairy Ease influenced symptoms: Lactrase reduced pain, bloating and total symptomatic scores (P < 0.05), whereas Dairy Ease only reduced pain (P < 0.05). Lactaid administration did not reduce symptoms. Conclusion: In lactose‐intolerant subjects, the available lactase preparations differ in their ability to improve both breath hydrogen excretion and symptoms. Lactrase may be the product of choice for achieving symptomatic improvement.
AB - Objective: To compare the efficacy of three commercially available oral lactase preparations in adults with lactose intolerance. Methods: Design—Prospective, randomized, placebo‐controlled trial. Setting—Outpatient study in a General Clinical Research Center. Subjects—Ten lactose‐intolerant healthy volunteers were challenged with ice cream containing 18 g of lactose. Lactase or placebo was given immediately prior to challenge. Measurements—Symptoms and breath hydrogen excretion were recorded for 3 h following lactose challenge. Results: The three products differed in their abilities to influence symptoms and breath hydrogen excretion. Only Lactaid reduced the breath hydrogen excretion with lactose (mean peak, area under the curve and cumulative breath hydrogen excretion) (P < 0.05). Lactrase and Dairy Ease influenced symptoms: Lactrase reduced pain, bloating and total symptomatic scores (P < 0.05), whereas Dairy Ease only reduced pain (P < 0.05). Lactaid administration did not reduce symptoms. Conclusion: In lactose‐intolerant subjects, the available lactase preparations differ in their ability to improve both breath hydrogen excretion and symptoms. Lactrase may be the product of choice for achieving symptomatic improvement.
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U2 - 10.1111/j.1572-0241.1994.tb07919.x
DO - 10.1111/j.1572-0241.1994.tb07919.x
M3 - Article
C2 - 8147360
AN - SCOPUS:0028220158
SN - 0002-9270
VL - 89
SP - 566
EP - 570
JO - The American Journal of Gastroenterology
JF - The American Journal of Gastroenterology
IS - 4
ER -