Alkaptonuria diagnosed by flexible bronchoscopy

Joseph G. Parambil; Craig E. Daniels; Kenton J. Zehr; James P. Utz

doi:10.1378/chest.128.5.3678

Alkaptonuria diagnosed by flexible bronchoscopy

Joseph G. Parambil, Craig E. Daniels, Kenton J. Zehr, James P. Utz

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A 68-year-old white man was evaluated for failure to wean from mechanical ventilation after cardiac surgery. Bronchoscopy performed prior to percutaneous dilatational tracheotomy revealed circumferential strikingly dark-colored airways, most prominent in the trachea and mainstem bronchi, extending distally into all airways with overlying desiccated black secretions. Histologic examination of bronchial mucosal biopsy samples and the desiccated secretions showed acute bronchitis and necrotic debris, respectively. This finding and the patient's history led to testing for plasma homogentisic acid, which was found to be elevated at 12.6 μg/mL, establishing the first diagnosis of alkaptonuria made using flexible bronchoscopy.

Original language	English (US)
Pages (from-to)	3678-3680
Number of pages	3
Journal	Chest
Volume	128
Issue number	5
DOIs	https://doi.org/10.1378/chest.128.5.3678
State	Published - Nov 2005

Keywords

Alkaptonuria
Bronchoscopy
Homogentisic acid

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1378/chest.128.5.3678

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title = "Alkaptonuria diagnosed by flexible bronchoscopy",

abstract = "A 68-year-old white man was evaluated for failure to wean from mechanical ventilation after cardiac surgery. Bronchoscopy performed prior to percutaneous dilatational tracheotomy revealed circumferential strikingly dark-colored airways, most prominent in the trachea and mainstem bronchi, extending distally into all airways with overlying desiccated black secretions. Histologic examination of bronchial mucosal biopsy samples and the desiccated secretions showed acute bronchitis and necrotic debris, respectively. This finding and the patient's history led to testing for plasma homogentisic acid, which was found to be elevated at 12.6 μg/mL, establishing the first diagnosis of alkaptonuria made using flexible bronchoscopy.",

keywords = "Alkaptonuria, Bronchoscopy, Homogentisic acid",

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AU - Parambil, Joseph G.

AU - Daniels, Craig E.

AU - Zehr, Kenton J.

AU - Utz, James P.

PY - 2005/11

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N2 - A 68-year-old white man was evaluated for failure to wean from mechanical ventilation after cardiac surgery. Bronchoscopy performed prior to percutaneous dilatational tracheotomy revealed circumferential strikingly dark-colored airways, most prominent in the trachea and mainstem bronchi, extending distally into all airways with overlying desiccated black secretions. Histologic examination of bronchial mucosal biopsy samples and the desiccated secretions showed acute bronchitis and necrotic debris, respectively. This finding and the patient's history led to testing for plasma homogentisic acid, which was found to be elevated at 12.6 μg/mL, establishing the first diagnosis of alkaptonuria made using flexible bronchoscopy.

AB - A 68-year-old white man was evaluated for failure to wean from mechanical ventilation after cardiac surgery. Bronchoscopy performed prior to percutaneous dilatational tracheotomy revealed circumferential strikingly dark-colored airways, most prominent in the trachea and mainstem bronchi, extending distally into all airways with overlying desiccated black secretions. Histologic examination of bronchial mucosal biopsy samples and the desiccated secretions showed acute bronchitis and necrotic debris, respectively. This finding and the patient's history led to testing for plasma homogentisic acid, which was found to be elevated at 12.6 μg/mL, establishing the first diagnosis of alkaptonuria made using flexible bronchoscopy.

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KW - Homogentisic acid

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Alkaptonuria diagnosed by flexible bronchoscopy

Abstract

Keywords

ASJC Scopus subject areas

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