Aldosteronomas-State of the Art

Travis J. McKenzie, Joseph B. Lillegard, William Francis Young, Geoffrey B. Thompson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Primary aldosteronism (PA) is the most common cause of secondary hypertension in nonsmokers. Widespread screening of unselected hypertensives has identified PA in as many as 15% of patients. With such screening efforts using the PAC/PRA ratio and PAC, the widespread prevalence of the disease has become apparent while the relative percentage of APA has decreased. PA is confirmed by demonstrating lack of aldosterone suppressibility with sodium loading. Subtype evaluation is best achieved with high resolution CT scanning and AVS in the appropriate setting. In patients with PA and a unilateral source of aldosterone excess, laparoscopic adrenalectomy is the treatment of choice with excellent outcomes and low morbidity as compared with older open approaches. Patients with IHA, or those not amenable or agreeable to surgery, are best managed with a MR antagonist.

Original languageEnglish (US)
Pages (from-to)1241-1253
Number of pages13
JournalSurgical Clinics of North America
Volume89
Issue number5
DOIs
StatePublished - Oct 2009

Fingerprint

Hyperaldosteronism
Aldosterone
Adrenalectomy
Sodium
Hypertension
Morbidity
Therapeutics

Keywords

  • Adrenal vein sampling
  • Aldosterone-producing adenoma
  • Aldosteronoma
  • Idiopathic hyperplasia
  • Primary aldosteronism

ASJC Scopus subject areas

  • Surgery

Cite this

McKenzie, T. J., Lillegard, J. B., Young, W. F., & Thompson, G. B. (2009). Aldosteronomas-State of the Art. Surgical Clinics of North America, 89(5), 1241-1253. https://doi.org/10.1016/j.suc.2009.06.017

Aldosteronomas-State of the Art. / McKenzie, Travis J.; Lillegard, Joseph B.; Young, William Francis; Thompson, Geoffrey B.

In: Surgical Clinics of North America, Vol. 89, No. 5, 10.2009, p. 1241-1253.

Research output: Contribution to journalArticle

McKenzie, TJ, Lillegard, JB, Young, WF & Thompson, GB 2009, 'Aldosteronomas-State of the Art', Surgical Clinics of North America, vol. 89, no. 5, pp. 1241-1253. https://doi.org/10.1016/j.suc.2009.06.017
McKenzie, Travis J. ; Lillegard, Joseph B. ; Young, William Francis ; Thompson, Geoffrey B. / Aldosteronomas-State of the Art. In: Surgical Clinics of North America. 2009 ; Vol. 89, No. 5. pp. 1241-1253.
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