Abstract
Heart failure is a major health problem of epidemic proportions. Irrespective of its etiologic origins, a dysfunction of this normally efficient muscular pump is associated with systemic consequences, a progressive downhill clinical course and poor prognosis. Ventricular dysfunction is ultimately accompanied by neurohormonal system activation that accounts for: the congestive heart failure syndrome; an induction of oxi/nitrosative stress; adverse vascular remodeling; and activation of the immune system that contributes to a wasting syndrome known as cardiac cachexia. Circulating effector hormones of the renin-angiotensin-aldosterone system are an integral feature of this neurohormonal activation; they have systemic consequences. Insights into the pathophysiology of heart failure will identify improved methods of prevention, including biomarkers to aid in its detection and identification of risk, and to the development of specific drug targets. Herein we address one aspect of the neurohormonal profile of heart failure, namely that related to aldosteronism. Our focus is directed at the link between aldosteronism and its adverse influence on coronary vasculature structure, a proinflammatory/fibrogenic cardiac phenotype, which is based on an immunostimulatory state that includes activated peripheral blood mononuclear cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 505-516 |
| Number of pages | 12 |
| Journal | Current Drug Targets |
| Volume | 4 |
| Issue number | 6 |
| State | Published - Aug 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
Cite this
Aldosteronism in heart failure : A proinflammatory/fibrogenic cardiac phenotype. Search for biomakers and potential drug targets. / Weber, Karl T.; Gerling, Ivan C.; Kiani, Mohammad F.; Guntaka, Ramareddy V.; Sun, Yao; Ahokas, Robert A.; Postlethwaite, Arnold E.; Warrington, Kenneth J.
In: Current Drug Targets, Vol. 4, No. 6, 08.2003, p. 505-516.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aldosteronism in heart failure
T2 - A proinflammatory/fibrogenic cardiac phenotype. Search for biomakers and potential drug targets
AU - Weber, Karl T.
AU - Gerling, Ivan C.
AU - Kiani, Mohammad F.
AU - Guntaka, Ramareddy V.
AU - Sun, Yao
AU - Ahokas, Robert A.
AU - Postlethwaite, Arnold E.
AU - Warrington, Kenneth J
PY - 2003/8
Y1 - 2003/8
N2 - Heart failure is a major health problem of epidemic proportions. Irrespective of its etiologic origins, a dysfunction of this normally efficient muscular pump is associated with systemic consequences, a progressive downhill clinical course and poor prognosis. Ventricular dysfunction is ultimately accompanied by neurohormonal system activation that accounts for: the congestive heart failure syndrome; an induction of oxi/nitrosative stress; adverse vascular remodeling; and activation of the immune system that contributes to a wasting syndrome known as cardiac cachexia. Circulating effector hormones of the renin-angiotensin-aldosterone system are an integral feature of this neurohormonal activation; they have systemic consequences. Insights into the pathophysiology of heart failure will identify improved methods of prevention, including biomarkers to aid in its detection and identification of risk, and to the development of specific drug targets. Herein we address one aspect of the neurohormonal profile of heart failure, namely that related to aldosteronism. Our focus is directed at the link between aldosteronism and its adverse influence on coronary vasculature structure, a proinflammatory/fibrogenic cardiac phenotype, which is based on an immunostimulatory state that includes activated peripheral blood mononuclear cells.
AB - Heart failure is a major health problem of epidemic proportions. Irrespective of its etiologic origins, a dysfunction of this normally efficient muscular pump is associated with systemic consequences, a progressive downhill clinical course and poor prognosis. Ventricular dysfunction is ultimately accompanied by neurohormonal system activation that accounts for: the congestive heart failure syndrome; an induction of oxi/nitrosative stress; adverse vascular remodeling; and activation of the immune system that contributes to a wasting syndrome known as cardiac cachexia. Circulating effector hormones of the renin-angiotensin-aldosterone system are an integral feature of this neurohormonal activation; they have systemic consequences. Insights into the pathophysiology of heart failure will identify improved methods of prevention, including biomarkers to aid in its detection and identification of risk, and to the development of specific drug targets. Herein we address one aspect of the neurohormonal profile of heart failure, namely that related to aldosteronism. Our focus is directed at the link between aldosteronism and its adverse influence on coronary vasculature structure, a proinflammatory/fibrogenic cardiac phenotype, which is based on an immunostimulatory state that includes activated peripheral blood mononuclear cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0038268569&partnerID=8YFLogxK
M3 - Article
C2 - 12866665
AN - SCOPUS:0038268569
VL - 4
SP - 505
EP - 516
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
IS - 6
ER -